公开(公告)号：US20210290759A1

公开(公告)日：2021-09-23

申请号：US17216619

申请日：2021-03-29

申请人： BRAVOVAX CO., LTD

发明人： Ting MU ,  Ping ZHAO ,  Long XU ,  Yang XIAO ,  Jean-philippe JULIEN ,  Yue WU ,  Liang XIE ,  Xueting CHEN ,  Qi LIU ,  Charles Dwo Yuan SIA ,  Pele Choi Sing CHONG ,  Michel KLEIN ,  Linsen DU ,  Ke WU

IPC分类号： A61K39/25 ,  C07K14/04 ,  C07K14/255 ,  C12N15/86 ,  C12N15/70 ,  C12N15/62

摘要： A prokaryotic expression system or a recombinant adenovirus system is used to highly efficiently express VZV envelope gE glycoprotein and the flagellin fusion protein thereof. The produced recombinant gE protein, gE flagellin fusion protein and recombinant adenovirus vector, or composition thereof is used to immunize a mouse so as to promote the body to generate gE and VZV-specific antibody titer, as well as gE-specific and VZV-specific cell immunity.