公开(公告)号：US3813376A

公开(公告)日：1974-05-28

申请号：US28576472

申请日：1972-08-31

申请人： BRISTOL MYERS CO

发明人： NAITO T ,  OKUMURA J

IPC分类号： C07C45/28 ,  C07C205/56 ,  C07D501/36 ,  C07D99/24

CPC分类号： C07C205/56 ,  C07C45/28 ,  C07C49/67

摘要： 7-(O-AMINOMEHYLPHENYLACETAMIDO) - 3 - (3-HYDROXYPYRIDAZIN-6 - YLTHIOMETHYL) - 3 - CEPHEN-4-CARBOXYLIC ACID AND ITS NONTOXIC PHARMACEUTICALLY ACCEPTABLE SALTS AND ESPECIALLY ITS DIMETHANESULFONATE DERIVATIVE ARE VAUABLE AS ANTIBACTERIAL AGENTS, AS NUTRITIONAL SUPPLEMENTS IN ANIMAL FEEDS AND AS THERAPEUTIC AGENTS IN POULTRY AND ANIMALS, INCLUDING MAN, AND ARE ESPECIALLY USEFUL IN THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY MANY GRAMPOSITIVE AND GRAM-NEGATIVE BACTERIA. 1-(O-AMINOMETHYLPHENYLACETAMIDO) - 3 = (3 - HYDROXY-PYRIDAZIN-6-YLTHIOMETHYL) - 3 - CEPHEM - 4-CARBOXYLIC ACID IS PREPARED FOR EXAMPLE, BY TREATMENT AT 0*C. WITH TRIFLUOROACETIC ACID OF THE CORRESPONDING COMPOUND IN WHICH THE FREE AMINO GROUP IS PROTECTED WITH A TERT.-BUTOXYCARBONYL GROUP.

公开(公告)号：US3813390A

公开(公告)日：1974-05-28

申请号：US28663072

申请日：1972-09-06

申请人： BRISTOL MYERS CO

发明人： NAITO T ,  OKUMURA J

IPC分类号： C07D501/18 ,  C07D501/36 ,  C07D99/24

CPC分类号： C07D501/36 ,  Y02P20/55

摘要： 7-(O-AMINOMETHYLPHENYLTHIOACETAMIDO) - 3 - (3 - HYDROXY-PYRIDAZIN-6-YLTHIOMETHYL))-3-CEPHEM - 4 - CARBOXYLIC ACID AND ITS NONTOXIC, PHARMACEUTICALLY ACCEPTABLE SALTS AND ESPECIALLY ITS DIMETHANESULFONATE DERIVATIVE ARE VALUABLE AS ANTIBACTERIAL AGENTS, AS NUTRITIONAL SUPPLEMENTS IN ANIMAL FEEDS AND AS THERAPEUTIC AGENTS IN POULTRY AND ANIMALS, INCLUDING MAN, AND ARE ESPECIALLY USEFUL IN THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY MANY GRAMPOSITIIVE AND GRAM-NEGATIVE BACTERIA. 7-(O-AMINOMETHYLPHENYLTHIOACETAMIDO)-3-(3-HYDOXY-PYRIDAZIN - 6 - YLTHIOMETHYL)-3-CEPHEM-4-CARBOXYLIC ACID IS PREPARED, FOR EXAMPLE, BY TREATMENT OF 0*C. WITH TRIFLUOROACETIC ACID OF THE CORRESPONDING COMPOUND IN WHICH THE FREE AMINO GROUP IS PROTECTED WITH A TERT.-BUTOXYCARBONYL GROUP.

公开(公告)号：US3796716A

公开(公告)日：1974-03-12

申请号：US3796716D

申请日：1972-03-22

申请人： BRISTOL MYERS CO

发明人： NAITO T ,  OKUMURA J

IPC分类号： C07C67/00 ,  C07C227/00 ,  C07C227/22 ,  C07C229/34 ,  C07D217/24 ,  C07D33/16

CPC分类号： C07D217/24

摘要： YIELDS IN THE PRODUCTION OF O-AMINOMETHYLPHENYLACETIC ACID ARE IMPROVED BY FIRST REACTING 2-INDANONE WITH SODIUM AZIDE AND SULFURIC ACID TO PRODUCE O-AMINOMETHYL PHENYLACETIC ACID LACTAM WHICH IS THEN REFLUXED IN HYDROCHLORIC ACID TO PRODUCE O-AMINOMETHYLPHENYLACETIC ACID HYDROCHLORIDE.

公开(公告)号：US3823141A

公开(公告)日：1974-07-09

申请号：US28679272

申请日：1972-09-06

申请人： BRISTOL MYERS CO

发明人： NAITO T ,  OKUMURA J

IPC分类号： C07D501/36 ,  H04L25/20 ,  C07D99/24

CPC分类号： H04L25/20

摘要： 7 - (O - AMINOMETHYL - P - HYDROXYPHENYLACETAMIDO)-3(3 - HYDROXY - PYRIDAZIN - 6 - YLTHIOMETHYL) - 3 - CEPHEM4-CARBOXYLIC ACID AND AND ITS NONTOXIC, PHARMACEUTICALLY ACCEPTABLE SALTS AND ESPECIALLY ITS DIMETHANESULFONATE DERIVATIVE ARE VALUABLE AS ANTIBACTERIA AGENTS, AS NUTRITIONAL SUPPLEMENTS IN AMINAL FEEDS AND AS THERAPEUTIC AGENTS IN POULTRY AND ANIMALS, INCLUDING MAN, AND ARE ESPECIALLY USEFUL IN THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY MANY GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA. 7-(0AMINOMETHYLPHENYL - P - HYDROXYACETAMIDO) - 3 - )3HYDROXYPYRIDAZIN - 6 - YLTHIOMETHYL) - 3 - (3CARBOXYLIC ACID IS PREPARED, FOR EXAMPLE, BY TREATMENT AT 0*C. WITH TRIFLUOROACETIC ACID OF THE CORRESPONDING COMPOUND IN WHICH THE FREE AMINO GROUP IS PROTECTED WITH A TERT-BUTOXYCARBONYL GROUP.

公开(公告)号：US3814755A

公开(公告)日：1974-06-04

申请号：US28479272

申请日：1972-08-30

申请人： BRISTOL MYERS CO

发明人： NAITO T ,  OKUMURA J ,  KAMACHI H

IPC分类号： C07C229/34 ,  A61K20060101 ,  C07C67/00 ,  C07C227/00 ,  C07C227/04 ,  C07C227/06 ,  C07D20060101 ,  C07D501/36 ,  C07D519/00 ,  C07D519/06 ,  C07D99/24

CPC分类号： Y02P20/55

摘要： 7-(O-AMINOMETHYLPHENYLACETAMIDO)-3-(TETRAZOLO(4,5-B)PYRIDAZIN-6 -YLTHIOMETHYL)-3-CEPHEM-CARBOXYLIC ACID AND ITS NONTOXIC, PHARMACEUTICALLY ACCEPTABLE SALTS AND ESPECIALLY ITS DIMETHANESULFONATE DERIVATIVE ARE VALUEABLE AS ANTIBACTERIA AGENTS, AS NUTRITIONAL SUPPLEMENTS IN ANIMAL FEEDS AND AS THERAPEUTICAL AGENTS IN POULTRY AND ANIMALS, INCLUDING MAN, AND ARE ESPECIALLY USEFUL IN THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY MANY GRAMPOSITIVE AND GRAM-NEGATIVE BACTERIA. 7-(O-AMINOMETHYLPHENYLACETAMIDO)-3-TETRAZOLO(4,5-B)PYRIDAZIN-6-YLTHIOMETHYL)-3-CEPHEM-4-CARBOXYLIC ACID IS PREPARED, FOR EXAMPLE, BY TREATMENT AT 0*C. WITH TRIFLUOROACETIC ACID OF THE CORRESPONDING COMPOUND IN WHICH THE FREE AMINO GROUP IS PROTECTED WITH A TERT-BUTOXYCARBONYL GROUP.

公开(公告)号：US3813391A

公开(公告)日：1974-05-28

申请号：US28679372

申请日：1972-09-06

申请人： BRISTOL MYERS CO

发明人： KAMACHI H ,  NAITO T ,  OKUMURA J

IPC分类号： C07D501/18 ,  C07D501/24 ,  C07D501/36 ,  C07D99/24

摘要： 7 - (B-(O-AMINOMETHYLPHENYL)PROPIONAMIDO)-3-(TETRAZOLO(4,5-B)PYRIDAZIN - 6 - YLTHIOMETHYL) - 3 - CEPHEM-4CARBOXYLIC ACID AND ITS NONTOXIC, PHARMACEUTICALLY ACCEPTABLE SALTS AND ESPECIALLY ITS DIMETHANEUSLFONATE DEIVATIVE ARE VALUABLE AS ANTIBACTERRIAL AGENTS, AS NUTRITIONAL SUPPLEMENTS IN ANIMAL FEEDS AND AS THERAPEUTIC AGENTS IN POULTRY AND ANIMALS, INCLUDING MAN, AND ARE ESPECIALLY USEFUL IN THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY MANY GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIAL. 7-(B-(OAMINOMETHYLPHENYL)PROPIONAMIDO)-3-(TETRAZOLO(4,5 - B) PYRIDAZIN-6-YLTHIOMETHYL)-3-CEPHEM-4 - CARBOXYLIC ACID IS PREPARED, FOR EXAMPLE, BY TREATEMNT AT 0*C. WITH TRIFLUOROACETIC ACID OF THE CORRESPONDING COMPOUND IN WHICH THE FREE AMINO GROUP IS PROTECTED WITH A TERT.BUTOXYCARBONYL GROUP.