公开(公告)号：US20220324840A1

公开(公告)日：2022-10-13

申请号：US17713598

申请日：2022-04-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Chen ,  Godwin Kwame Kumi ,  Audris Huang ,  Satheesh Kesavan Nair ,  Bharat Dinkar Shimpukade ,  Suresh Babu Vishwa Krishna Penmetsa ,  James Aaron Balog

IPC: C07D401/14 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein R1, R2, R4, R6, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US11718601B2

公开(公告)日：2023-08-08

申请号：US17713598

申请日：2022-04-05

Applicant: Bristol-Myers Squibb Company

Inventor： Yan Chen ,  Godwin Kwame Kumi ,  Audris Huang ,  Satheesh Kesavan Nair ,  Bharat Dinkar Shimpukade ,  Suresh Babu Vishwa Krishna Penmetsa ,  James Aaron Balog

IPC: C07D401/14 ,  A61P35/00

CPC classification number: C07D401/14 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I):




or a salt thereof, wherein R1, R2, R4, R6, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US20240376082A1

公开(公告)日：2024-11-14

申请号：US18740857

申请日：2024-06-25

Applicant: Bristol-Myers Squibb Company

Inventor： Yan Chen ,  Godwin Kwame Kumi ,  Audris Huang ,  Satheesh Kesavan Nair ,  Bharat Dinkar Shimpukade ,  Suresh Babu Vishwa Krishna Penmetsa ,  James Aaron Balog

IPC: C07D401/14 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein R1, R2, R4, R6, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US20230303527A1

公开(公告)日：2023-09-28

申请号：US18331348

申请日：2023-06-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Chen ,  Godwin Kwame Kumi ,  Audris Huang ,  Satheesh Kesavan Nair ,  Bharat Dinkar Shimpukade ,  Suresh Babu Vishwa Krishna Penmetsa ,  James Aaron Balog

IPC: C07D401/14 ,  A61P35/00

CPC classification number: C07D401/14 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I):




or a salt thereof, wherein R1, R2, R4, R6, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.