公开(公告)号：US09725449B2

公开(公告)日：2017-08-08

申请号：US15150492

申请日：2016-05-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Derek J. Norris ,  Wayne Vaccaro ,  Mikkel V. DeBenedetto ,  Andrew P. Degnan ,  George V. Delucca ,  Jeffrey A. Deskus ,  Wen-Ching Han ,  Godwin Kwame Kumi ,  William D. Schmitz ,  John E. Starrett, Jr. ,  Matthew D. Hill ,  Hong Huang

IPC: C07D471/14 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/554 ,  A61K31/675 ,  A61K31/683 ,  C07D519/00 ,  C07F9/6561

CPC classification number: C07D471/14 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/554 ,  A61K31/675 ,  A61K31/683 ,  C07D519/00 ,  C07F9/6561

Abstract: The present invention is directed to tricyclic compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

公开(公告)号：US11166959B2

公开(公告)日：2021-11-09

申请号：US16761449

申请日：2018-11-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Erika M. V. Araujo ,  Yan Chen ,  Bireshwar Dasgupta ,  Andrew P. Degnan ,  Matthew D. Hill ,  Godwin Kwame Kumi ,  Harold A. Mastalerz ,  Mark D. Wittman ,  Bradley C. Pearce ,  Guifen Zhang

IPC: A61K31/5377 ,  A61K31/506 ,  A61P35/00 ,  A61K45/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D453/02 ,  C07D491/048 ,  C07D498/10 ,  C07D519/00

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is CH or N; Y is CR5 or N; and R1, R2, R3, R4, and R5 are defined herein. Also disclosed are methods of using such compounds to modulate or inhibit the enzymatic activity of hematopoietic progenitor kinase 1 (HPK1), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US20160333013A1

公开(公告)日：2016-11-17

申请号：US15150492

申请日：2016-05-10

Applicant: Bristol-Myers Squibb Company

Inventor： Derek J. Norris ,  Wayne Vaccaro ,  Mikkel V. DeBenedetto ,  Andrew P. Degnan ,  George V. Delucca ,  Jeffrey A. Deskus ,  Wen-Ching Han ,  Godwin Kwame Kumi ,  William D. Schmitz ,  John E. Starrett, JR. ,  Matthew D. Hill ,  Hong Huang

IPC: C07D471/14 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/444 ,  A61K31/541 ,  A61K31/675 ,  A61K31/4545 ,  C07D519/00 ,  A61K31/439 ,  A61K31/554 ,  C07F9/6561 ,  A61K31/683 ,  A61K31/4375 ,  A61K31/519

CPC classification number: C07D471/14 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/554 ,  A61K31/675 ,  A61K31/683 ,  C07D519/00 ,  C07F9/6561

Abstract: The present invention is directed to tricyclic compounds of the formula wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

Abstract translation: 其中所有取代基在本文中定义，以及包含本发明化合物的药学上可接受的组合物以及使用所述组合物治疗各种疾病的方法。

公开(公告)号：US20240376082A1

公开(公告)日：2024-11-14

申请号：US18740857

申请日：2024-06-25

Applicant: Bristol-Myers Squibb Company

Inventor： Yan Chen ,  Godwin Kwame Kumi ,  Audris Huang ,  Satheesh Kesavan Nair ,  Bharat Dinkar Shimpukade ,  Suresh Babu Vishwa Krishna Penmetsa ,  James Aaron Balog

IPC: C07D401/14 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein R1, R2, R4, R6, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US20230303527A1

公开(公告)日：2023-09-28

申请号：US18331348

申请日：2023-06-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Chen ,  Godwin Kwame Kumi ,  Audris Huang ,  Satheesh Kesavan Nair ,  Bharat Dinkar Shimpukade ,  Suresh Babu Vishwa Krishna Penmetsa ,  James Aaron Balog

IPC: C07D401/14 ,  A61P35/00

CPC classification number: C07D401/14 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I):




or a salt thereof, wherein R1, R2, R4, R6, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US20220324840A1

公开(公告)日：2022-10-13

申请号：US17713598

申请日：2022-04-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Chen ,  Godwin Kwame Kumi ,  Audris Huang ,  Satheesh Kesavan Nair ,  Bharat Dinkar Shimpukade ,  Suresh Babu Vishwa Krishna Penmetsa ,  James Aaron Balog

IPC: C07D401/14 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein R1, R2, R4, R6, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US20210147383A1

公开(公告)日：2021-05-20

申请号：US16950978

申请日：2020-11-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Andrew P. DEGNAN ,  Godwin Kwame Kumi ,  Audris Huang ,  James Aaron Balog ,  Ashok Vinayak Purandare ,  Weifang Shan ,  Guo Li

IPC: C07D401/14 ,  C07D405/14 ,  C07D487/04 ,  C07D417/14 ,  C07D498/18

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: Z is CR6R6 or C═O; Ring A is: and R1, R2, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US20230322803A1

公开(公告)日：2023-10-12

申请号：US17913206

申请日：2021-03-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Andrew P. Degnan ,  Godwin Kwame Kumi ,  Andrew J. Tebben ,  Audris Huang ,  Peter Kinam Park ,  Donna M. Bilder ,  Emily Charlotte Cherney ,  Ashok Vinayak Purandare

IPC: C07D498/04 ,  C07D471/04 ,  C07D401/14

CPC classification number: C07D498/04 ,  C07D401/14 ,  C07D471/04

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein Ring A is a carbon-linked ring; and Ring A, R1, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US11718601B2

公开(公告)日：2023-08-08

申请号：US17713598

申请日：2022-04-05

Applicant: Bristol-Myers Squibb Company

Inventor： Yan Chen ,  Godwin Kwame Kumi ,  Audris Huang ,  Satheesh Kesavan Nair ,  Bharat Dinkar Shimpukade ,  Suresh Babu Vishwa Krishna Penmetsa ,  James Aaron Balog

IPC: C07D401/14 ,  A61P35/00

CPC classification number: C07D401/14 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I):




or a salt thereof, wherein R1, R2, R4, R6, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US11548870B2

公开(公告)日：2023-01-10

申请号：US16950978

申请日：2020-11-18

Applicant: Bristol-Myers Squibb Company

Inventor： Andrew P. Degnan ,  Godwin Kwame Kumi ,  Audris Huang ,  James Aaron Balog ,  Ashok Vinayak Purandare ,  Weifang Shan ,  Guo Li

IPC: C07D407/14 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D491/107 ,  A61K31/4439 ,  A61P35/00 ,  C07D405/14 ,  C07D498/18

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: Z is CR6R6 or C═O; Ring A is: and R1, R2, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.