公开(公告)号：US09234028B2

公开(公告)日：2016-01-12

申请号：US13956952

申请日：2013-08-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ray Camphausen ,  Brent Morse ,  Stuart Emanuel ,  David Fabrizio

IPC: A61K38/17 ,  A61K38/39 ,  C07K14/78 ,  C07K14/435 ,  C07K16/28 ,  C07K14/765 ,  C07K14/79 ,  C07K19/00

CPC classification number: C07K14/78 ,  A61K38/00 ,  C07K14/765 ,  C07K14/79 ,  C07K16/2863 ,  C07K19/00 ,  C07K2317/31 ,  C07K2318/20 ,  C07K2319/30

Abstract: The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.

公开(公告)号：US09920108B2

公开(公告)日：2018-03-20

申请号：US14954596

申请日：2015-11-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ray Camphausen ,  Brent Morse ,  Stuart Emanuel ,  David Fabrizio

IPC: C07K14/78 ,  C07K16/28 ,  C07K14/76 ,  C07K14/765 ,  C07K14/79 ,  C07K19/00 ,  A61K38/00

CPC classification number: C07K14/78 ,  A61K38/00 ,  C07K14/765 ,  C07K14/79 ,  C07K16/2863 ,  C07K19/00 ,  C07K2317/31 ,  C07K2318/20 ,  C07K2319/30

Abstract: The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.

公开(公告)号：US10781247B2

公开(公告)日：2020-09-22

申请号：US15886118

申请日：2018-02-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ray Camphausen ,  Brent Morse ,  Stuart Emanuel ,  David Fabrizio

IPC: C07K14/78 ,  C07K16/28 ,  C07K14/76 ,  C07K14/765 ,  C07K14/79 ,  C07K19/00 ,  A61K38/00

Abstract: The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.