公开(公告)号：US11008301B2

公开(公告)日：2021-05-18

申请号：US16619960

申请日：2018-06-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Pravin Sudhakar Shirude ,  Amit Kumar Chattopadhyay ,  Chandrasekhar Rachamreddy ,  Nicholas R. Wurtz ,  Ellen K. Kick

IPC: C07D401/10 ,  A61P9/00 ,  C07D401/14 ,  C07D413/14 ,  C07D491/107 ,  C07D498/08

Abstract: The disclosure relates to compounds of formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, and related diseases.

公开(公告)号：US20200207735A1

公开(公告)日：2020-07-02

申请号：US16619960

申请日：2018-06-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Pravin Sudhakar Shirude ,  Amit Kumar Chattopadhyay ,  Chandrasekhar Rachamreddy ,  Nicholas R. Wurtz ,  Ellen K. Kick

IPC: C07D401/10 ,  C07D498/08 ,  C07D401/14 ,  C07D413/14 ,  C07D491/107 ,  A61P9/00

Abstract: The disclosure relates to compounds of formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, and related diseases.