公开(公告)号：US09738655B2

公开(公告)日：2017-08-22

申请号：US14777763

申请日：2014-03-25

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Donald J. P. Pinto ,  Charles G. Clarke ,  Leon M. Smith, II ,  Michael J. Orwat ,  Yoon Jeon ,  James R. Corte

IPC: A61K31/00 ,  C07D491/107 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/14 ,  C07D471/10 ,  C07D487/04 ,  C07D491/10

CPC classification number: C07D491/107 ,  C07D401/06 ,  C07D401/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/06 ,  C07D413/14 ,  C07D417/14 ,  C07D471/10 ,  C07D487/04 ,  C07D491/10

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.