公开(公告)号：US20130303467A1

公开(公告)日：2013-11-14

申请号：US13938763

申请日：2013-07-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jack Z. Gougoutas ,  Hildegard Lobinger ,  Srividya Ramakrishnan ,  Prashant P. Deshpande ,  Jeffrey T. Bien ,  Chiajen Lai ,  Chenchi Wang ,  Peter Riebel ,  John Anthony Grosso ,  Alexandra A. Nirschl ,  Janak Singh ,  John D. DiMarco

IPC: C07H15/207 ,  A61K45/06 ,  A61K31/7034

CPC classification number: C07H15/207 ,  A61K31/7034 ,  A61K45/06 ,  A61P3/10 ,  C07H7/04

Abstract: The present invention relates to physical crystal structures of a compound of the formula I: wherein R1, R2, R2a, R3 and R4 are as defined herein, especially pharmaceutical compositions containing structures of compound I or II, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.

Abstract translation: 本发明涉及式I化合物的物理结晶结构：其中R1，R2，R2a，R3和R4如本文所定义，特别是含有化合物I或II结构的药物组合物，其制备方法， 制备方法以及使用这种结构治疗糖尿病等疾病的方法。