公开(公告)号：US10407490B2

公开(公告)日：2019-09-10

申请号：US15568830

申请日：2016-04-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Mark R. Krystal ,  David L. Wensel ,  Jonathan Davis

IPC: A61K38/00 ,  A61P31/18 ,  C07K14/78 ,  A61K47/60 ,  C07K14/79 ,  C07K14/005 ,  C07K14/765

Abstract: The invention is directed to polypeptides comprising a CD4 binding moiety, a gp41 binding moiety, a HIV fusion peptide inhibitor moiety and combinations thereof. More specifically, the present invention relates to polypeptides comprising a fibronectin-based scaffold domain protein that binds CD4, a fibronectin-based scaffold domain protein that binds the N17 domain of gp41, and a HIV fusion peptide inhibitor or combinations thereof. The invention also relates to the use of the innovative proteins in therapeutic applications to treat HIV.