公开(公告)号：US20190382491A1

公开(公告)日：2019-12-19

申请号：US16529230

申请日：2019-08-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Maria Jure-Kunkel ,  David M. Berman ,  Alan J. Korman ,  Mark J. Selby ,  Suba Krishnan

IPC: C07K16/28 ,  C07K16/30

Abstract: This disclosure provides a method for treating a subject afflicted with a cancer, which method comprises administering to the subject therapeutically effective amounts of: (a) an antibody or an antigen-binding portion thereof that specifically binds to PD-1; and (b) an antibody or an antigen-binding portion thereof that specifically binds to CD 137.

公开(公告)号：US20170247455A1

公开(公告)日：2017-08-31

申请号：US15505299

申请日：2015-08-21

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Maria JURE-KUNKEL ,  David M. Berman ,  Alan J. Korman ,  Mark J. Selby ,  Suba Krishnan

IPC: C07K16/28 ,  C07K16/30

CPC classification number: C07K16/2818 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/545 ,  C07K16/2878 ,  C07K16/3061 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: This disclosure provides a method for treating a subject afflicted with a cancer, which method comprises administering to the subject therapeutically effective amounts of: (a) an antibody or an antigen-binding portion thereof that specifically binds to PD-1; and (b) an antibody or an antigen-binding portion thereof that specifically binds to CD137.