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1.发明申请公开(公告)号：US20170247455A1
公开(公告)日：2017-08-31
申请号：US15505299
申请日：2015-08-21
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Maria JURE-KUNKEL , David M. Berman , Alan J. Korman , Mark J. Selby , Suba Krishnan
CPC classification number: C07K16/2818 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/2878 , C07K16/3061 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: This disclosure provides a method for treating a subject afflicted with a cancer, which method comprises administering to the subject therapeutically effective amounts of: (a) an antibody or an antigen-binding portion thereof that specifically binds to PD-1; and (b) an antibody or an antigen-binding portion thereof that specifically binds to CD137.
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公开(公告)号：US11685787B2
公开(公告)日：2023-06-27
申请号：US16612956
申请日：2018-05-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Suba Krishnan , Penny E. Phillips , Zheng Yang , Haiqing Wang
CPC classification number: C07K16/2878 , A61P35/00 , C07K16/2818 , C07K16/2827 , A61K2039/507 , A61K2039/545 , C07K2317/75 , C07K2317/76
Abstract: Provided herein are methods for treating cancer, comprising administering to a subject having cancer a therapeutically effective amount of an anti-GITR antibody alone or together with an anti-PD-1 or anti-PD-L1 antibody.
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公开(公告)号：US20190382491A1
公开(公告)日：2019-12-19
申请号：US16529230
申请日：2019-08-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Maria Jure-Kunkel , David M. Berman , Alan J. Korman , Mark J. Selby , Suba Krishnan
Abstract: This disclosure provides a method for treating a subject afflicted with a cancer, which method comprises administering to the subject therapeutically effective amounts of: (a) an antibody or an antigen-binding portion thereof that specifically binds to PD-1; and (b) an antibody or an antigen-binding portion thereof that specifically binds to CD 137.
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