专利检索 ap:("BRISTOL-MYERS SQUIBB COMPANY") AND inv:"Donald J.P Pinto" 第 1 页

1.

发明申请
DIAMIDE MACROCYCLES AS FACTOR XIA INHIBITORS 审中-公开

公开(公告)号：US20180141932A1

公开(公告)日：2018-05-24

申请号：US15735322

申请日：2016-06-16

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Leon Smith II , Donald J.P Pinto , James R. Corte , William R. Ewing

IPC分类号： C07D403/14 , C07D401/14 , C07D401/04 , C07D403/12 , A61P7/02

CPC分类号： C07D403/14 , A61P7/02 , C07D401/04 , C07D401/14 , C07D403/12

摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.