公开(公告)号：US20230416364A1

公开(公告)日：2023-12-28

申请号：US18041433

申请日：2021-08-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Flavio SCHWARZ ,  Xiaodi DENG ,  Pavel STROP

IPC: C07K16/28 ,  C12N15/86 ,  C07K14/715 ,  A61K38/20 ,  A61P35/00

CPC classification number: C07K16/2818 ,  C12N15/86 ,  C07K14/715 ,  A61K38/00 ,  A61P35/00 ,  C12N2740/15043 ,  C07K2319/30 ,  A61K38/2013

Abstract: The present disclosure provides constructs comprising an anti-PDI antibody, or an alternative targeting moiety, fused to CD25 or an IL-2 binding fragment of CD25. Such constructs find use in treating human diseases, such as cancer.