公开(公告)号：US20230416364A1

公开(公告)日：2023-12-28

申请号：US18041433

申请日：2021-08-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Flavio SCHWARZ ,  Xiaodi DENG ,  Pavel STROP

IPC: C07K16/28 ,  C12N15/86 ,  C07K14/715 ,  A61K38/20 ,  A61P35/00

CPC classification number: C07K16/2818 ,  C12N15/86 ,  C07K14/715 ,  A61K38/00 ,  A61P35/00 ,  C12N2740/15043 ,  C07K2319/30 ,  A61K38/2013

Abstract: The present disclosure provides constructs comprising an anti-PDI antibody, or an alternative targeting moiety, fused to CD25 or an IL-2 binding fragment of CD25. Such constructs find use in treating human diseases, such as cancer.

公开(公告)号：US20220031860A1

公开(公告)日：2022-02-03

申请号：US17297830

申请日：2019-12-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Pavel STROP ,  Chetana RAO-NAIK ,  Xiaodi DENG ,  Paul O. SHEPPARD ,  Sean Matthew WEST ,  Jason Michael HOGAN ,  Sayumi YAMAZOE

IPC: A61K47/68 ,  C07K16/30

Abstract: Antibodies are modified by replacing amino acids in the heavy chain CH1, CH2, or CH3 or light chain constant region with selected replacement glutamine-containing sequences to render them amenable to conjugation by the enzyme transglutaminase.

公开(公告)号：US20220016260A1

公开(公告)日：2022-01-20

申请号：US17297796

申请日：2019-11-25

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Pavel STROP ,  Chetana RAO-NAIK ,  Xiaodi DENG ,  Paul O. SHEPPARD ,  Patrick G. HOLDER ,  Sayumi YAMAZOE

IPC: A61K47/68 ,  C07K16/18

Abstract: An antibody has a glutamine-containing extension at the C-terminus of a light chain thereof, making it suitable for conjugation via transglutaminase-mediated transamidation.