公开(公告)号：US20240391931A1

公开(公告)日：2024-11-28

申请号：US18294280

申请日：2022-08-04

Applicant: Bristol-Myers Squibb Company

Inventor： Laura Akullian D'Agostino ,  Xinchao Chen ,  Claudio Emundo Chuaqui ,  Hormoz Mazdiyasni ,  Guobin Miao ,  Deqiang Niu

IPC: C07D495/14 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/69 ,  A61P35/00 ,  C07D471/14 ,  C07D519/00 ,  C07F5/02

Abstract: Provided herein are tricyclic fused pyrimidine compounds, and pharmaceutically acceptable salts thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

公开(公告)号：US20230167131A1

公开(公告)日：2023-06-01

申请号：US17799028

申请日：2021-02-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Kumaravel Selvakumar ,  Venkatram Paidi ,  Srinivasan Thangathirupathy ,  Vijaya Kumar Cm ,  Tirupathi Rao Alajangi ,  Mallikarjun Reddy Sura ,  Krishna Mahadevu ,  Ramesh Kumar Sistla ,  Piyush Agarwal ,  Arul Mozhi Subbiah Karuppiah ,  Jalathi S. Nair ,  Ooha Morampudi ,  Manoranjan Panda ,  Joseph A. Tino ,  Robert J. Cherney ,  John V. Duncia ,  Daniel S. Gardner ,  T. G. Murali Dhar ,  Audrey Graham Ross ,  Paul E. Gormisky ,  Xiao Zhu ,  Boris M. Seletsky ,  Alyssa H. Antropow ,  Deqiang Niu ,  Zhengdong Zhu ,  Guobin Miao ,  Julio Herman Cuervo

IPC: C07D519/00 ,  C07D471/04 ,  C07D487/04 ,  C07D409/14 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D519/00 ,  C07D471/04 ,  C07D487/04 ,  C07D409/14 ,  C07D405/14 ,  C07D413/14

Abstract: The disclosure generally relates to substituted heterocyclic compounds of Formula (Ia), which are inhibitors of PAD4, method for preparing these compounds, pharmaceutical compositions comprising these compounds and use of these compounds in the treatment of a disease or a disorder associated with PAD4 enzyme activity.

公开(公告)号：US20240190890A1

公开(公告)日：2024-06-13

申请号：US18495004

申请日：2023-10-26

Applicant: Bristol-Myers Squibb Company ,  Celgene Corporation

Inventor： Xirui Hu ,  Lixin Qiao ,  Boris Seletsky ,  Matthew Patton ,  Min Cao ,  Farid van der Mei ,  Guobin Miao ,  Ivar McDonald ,  Carolyn Dzierba

IPC: C07D495/14

CPC classification number: C07D495/14

Abstract: The present invention provides compounds, compositions thereof, and methods of using the MK2 inhibitors of the Formula: