公开(公告)号：US20190270741A1

公开(公告)日：2019-09-05

申请号：US16347849

申请日：2017-11-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Pratik DEVASTHALE ,  Fang MOORE ,  Guohua ZHAO ,  Susan Nicole PIENIAZEK ,  Kumaravel SELVAKUMAR ,  Suresh DHANUSU ,  Manoranjan PANDA ,  Lawrence R. MARCIN

IPC: C07D471/04 ,  A61P35/00 ,  A61P1/16 ,  A61P13/12 ,  A61P11/00

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to αv-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of αv-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.

公开(公告)号：US20190263808A1

公开(公告)日：2019-08-29

申请号：US16347844

申请日：2017-11-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Guohua ZHAO ,  Pratik DEVASTHALE ,  Xiang-Yang YE ,  Kumaravel SELVAKUMAR ,  Suresh DHANUSU ,  Palanikumar BALASUBRAMANIAN ,  Leatte R. GUERNON ,  Rita CIVIELLO ,  Xiaojun HAN ,  Michael Frederick PARKER ,  Swanee E. JACUTIN-PORTE

IPC: C07D471/04 ,  A61P11/00 ,  A61P37/06 ,  A61P35/00 ,  A61P19/10 ,  C07D519/00

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to αv-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ay-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.