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1.发明申请公开(公告)号：US20190270741A1
公开(公告)日：2019-09-05
申请号：US16347849
申请日：2017-11-07
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Pratik DEVASTHALE , Fang MOORE , Guohua ZHAO , Susan Nicole PIENIAZEK , Kumaravel SELVAKUMAR , Suresh DHANUSU , Manoranjan PANDA , Lawrence R. MARCIN
IPC: C07D471/04 , A61P35/00 , A61P1/16 , A61P13/12 , A61P11/00
Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to αv-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of αv-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
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公开(公告)号：US20250154148A1
公开(公告)日：2025-05-15
申请号：US18759708
申请日：2024-06-28
Applicant: Bristol-Myers Squibb Company
Inventor： Brian Edward FINK , Pravin S. SHIRUDE , Amit Kumar CHATTOPADHYAY , Laxmi Narayan NANDA , Vishweshwaraiah BALIGAR , Balaji SESHADRI , T.G. Murali DHAR , Li-Qiang SUN , Zhizhen Barbara ZHENG , Manoranjan PANDA , Maximilian David PALKOWITZ , Sirish Kaushik LAKKARAJU , Moloy BANERJEE
IPC: C07D471/04 , A61K31/553 , A61P35/00
Abstract: The present disclosure provides KRAS inhibitors. Methods of treating cancers using the compounds are also provided.
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公开(公告)号：US20250163046A1
公开(公告)日：2025-05-22
申请号：US18759719
申请日：2024-06-28
Applicant: Bristol-Myers Squibb Company
Inventor： Brian Edward FINK , Pravin S. SHIRUDE , Amit Kumar CHATTOPADHYAY , Laxmi Narayan NANDA , Vishweshwaraiah BALIGAR , Balaji SESHADRI , T.G. Murali DHAR , Li-Qiang SUN , Zhizhen Barbara ZHENG , Manoranjan PANDA , Maximilian David PALKOWITZ , Sirish Kaushik LAKKARAJU , Moloy BANERJEE
IPC: C07D471/04 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5386 , A61K31/553 , A61K31/554 , A61P35/00 , C07D519/00
Abstract: The present disclosure provides KRAS inhibitors. Methods of treating cancers using the compounds are also provided.
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