公开(公告)号：US11166959B2

公开(公告)日：2021-11-09

申请号：US16761449

申请日：2018-11-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Erika M. V. Araujo ,  Yan Chen ,  Bireshwar Dasgupta ,  Andrew P. Degnan ,  Matthew D. Hill ,  Godwin Kwame Kumi ,  Harold A. Mastalerz ,  Mark D. Wittman ,  Bradley C. Pearce ,  Guifen Zhang

IPC: A61K31/5377 ,  A61K31/506 ,  A61P35/00 ,  A61K45/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D453/02 ,  C07D491/048 ,  C07D498/10 ,  C07D519/00

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is CH or N; Y is CR5 or N; and R1, R2, R3, R4, and R5 are defined herein. Also disclosed are methods of using such compounds to modulate or inhibit the enzymatic activity of hematopoietic progenitor kinase 1 (HPK1), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.