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1.发明申请公开(公告)号：US20190388553A1
公开(公告)日：2019-12-26
申请号：US16437047
申请日：2019-06-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ian S. Young , Sha Lou , Sanjeev Gangwar
Abstract: In antibody-drug conjugates having tubulysin analog as the warhead, according to formula (III) the acetate group in the Tuv subunit (dotted box) demonstrates improved stability against hydrolytic cleavage.
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公开(公告)号：US11020490B2
公开(公告)日：2021-06-01
申请号：US16437047
申请日：2019-06-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ian S. Young , Sha Lou , Sanjeev Gangwar
Abstract: In antibody-drug conjugates having tubulysin analog as the warhead, according to formula (III) the acetate group in the Tuv subunit (dotted box) demonstrates improved stability against hydrolytic cleavage.
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公开(公告)号：US10981914B2
公开(公告)日：2021-04-20
申请号：US16578733
申请日：2019-09-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ian S. Young , Sanjeev Gangwar , Shoshana L. Posy , Yam B. Poudel , Prasanna Sivaprakasam
IPC: C07D473/18 , C07D473/04
Abstract: Compounds having a structure according to formula (I), (II), or (III) where R1, R2, R3, R5 X1, X2, and X3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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公开(公告)号：US10457681B2
公开(公告)日：2019-10-29
申请号：US16103511
申请日：2018-08-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ian S. Young , Sanjeev Gangwar , Shoshana L. Posy , Yam B. Poudel , Prasanna Sivaprakasam
IPC: C07D473/18 , C07D473/04
Abstract: Compounds having a structure according to formula (I), (II), or (III) where R1, R2, R3, R5X1, X2, and X3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
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