公开(公告)号：US09657006B2

公开(公告)日：2017-05-23

申请号：US14897764

申请日：2014-06-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jeremy Richter ,  J. Alex Bates ,  Daniel L. Cheney

IPC: C07D401/12 ,  A61K31/4709 ,  C07D413/12 ,  C07D245/04 ,  C07D255/04

CPC classification number: C07D413/12 ,  C07D245/04 ,  C07D255/04 ,  C07D401/12

Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.

公开(公告)号：US10669258B2

公开(公告)日：2020-06-02

申请号：US16340172

申请日：2017-10-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jeremy M. Richter ,  J. Alex Bates

IPC: C07D213/74 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D401/12

Abstract: The present invention provides compounds of Formula (I) wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US12060347B2

公开(公告)日：2024-08-13

申请号：US17123265

申请日：2020-12-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Xiaojun Zhang ,  Eldon Scott Priestley ,  J. Alex Bates ,  Oz Scott Halpern ,  Samuel Kaye Reznik ,  Jeremy M. Richter

IPC: C07D417/04 ,  A61P7/04 ,  A61P9/10 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

CPC classification number: C07D417/04 ,  A61P7/04 ,  A61P9/10 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

Abstract: Disclosed are compounds of Formula (I) to (VIII):




or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

公开(公告)号：US20210163465A1

公开(公告)日：2021-06-03

申请号：US17123265

申请日：2020-12-16

Applicant: Bristol-Myers Squibb Company

Inventor： Xiaojun Zhang ,  Eldon Scott Priestley ,  J. Alex Bates ,  Oz Scott Halpern ,  Samuel Kaye Reznik ,  Jeremy M. Richter

IPC: C07D417/04 ,  A61P7/04 ,  A61P9/10 ,  C07D405/04 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00 ,  C07D403/04

Abstract: Disclosed are compounds of Formula (I) to (VIII): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

公开(公告)号：US20190308948A1

公开(公告)日：2019-10-10

申请号：US16340172

申请日：2017-10-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jeremy M. Richter ,  J. Alex Bates

IPC: C07D401/12 ,  C07D213/74 ,  C07D401/14 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04

Abstract: The present invention provides compounds of Formula (I) wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.