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公开(公告)号：US20210395392A1
公开(公告)日：2021-12-23
申请号：US17284119
申请日：2019-10-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Thomas E. Spires, Jr. , Michael Quigley , Virginie Lafont , Ginger C. Rakestraw , Linda Liang , Karen A. Augustine-Rauch
Abstract: This disclosure provides isolated antibodies that bind specifically to MerTK expressed on the surface of a cell and inhibit efferocytosis by the MerTK-expressing cell. The disclosure provides methods for treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an anti-MerTK antibody as monotherapy or in combination with a checkpoint inhibitor, such as an anti-PD-1 or anti-PD-L1 antibody.
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