公开(公告)号：US12139551B2

公开(公告)日：2024-11-12

申请号：US17299038

申请日：2019-12-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Anan Chuntharapai ,  Paul Blaine Mesko ,  Thomas E. Spires, Jr. ,  Gaby A. Terracina ,  Xi-Tao Wang

IPC: C07K16/00 ,  A61P35/00 ,  C07K16/40 ,  G01N1/30 ,  G01N33/574

Abstract: The disclosure provides antibodies that specifically bind human IDO and methods of use thereof. In some aspects, the disclosure is directed to methods of detecting IDO in a biological sample comprising contacting the biological sample with an antibody described herein.

公开(公告)号：US20210395392A1

公开(公告)日：2021-12-23

申请号：US17284119

申请日：2019-10-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Thomas E. Spires, Jr. ,  Michael Quigley ,  Virginie Lafont ,  Ginger C. Rakestraw ,  Linda Liang ,  Karen A. Augustine-Rauch

IPC: C07K16/40 ,  A61K47/68 ,  A61P35/00 ,  C07K16/28

Abstract: This disclosure provides isolated antibodies that bind specifically to MerTK expressed on the surface of a cell and inhibit efferocytosis by the MerTK-expressing cell. The disclosure provides methods for treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an anti-MerTK antibody as monotherapy or in combination with a checkpoint inhibitor, such as an anti-PD-1 or anti-PD-L1 antibody.