公开(公告)号：US20180000788A1

公开(公告)日：2018-01-04

申请号：US15541725

申请日：2016-01-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Peter W. Glunz ,  Doree F. Sitkoff ,  Navnath Dnyanoba ,  Mandar Shrikrishna Bodas ,  Rajeev S. Bhide ,  Sharanabasappa Patil ,  Kumaresan Chinnakotti ,  Prasanna Savanor Maddu Rao

IPC: A61K31/4178 ,  C07D471/04 ,  C07D413/10 ,  C07D403/10 ,  C07D401/14 ,  C07D401/10 ,  A61K31/498 ,  C07D487/04 ,  A61K31/422

CPC classification number: A61K31/4178 ,  A61K31/422 ,  A61K31/498 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  C07D413/10 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.