公开(公告)号：US11267811B2

公开(公告)日：2022-03-08

申请号：US16650403

申请日：2018-09-27

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Prasada Rao Jalagam ,  Satheesh Kesavan Nair ,  Manoranjan Panda ,  Ramakanth Sarabu ,  Jacob Swidorski ,  Brett R. Beno ,  Alicia Regueiro-Ren

IPC: C07D417/14 ,  C07D405/14

Abstract: The present disclosure relates to compounds of formula I, which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.

公开(公告)号：US20210122746A1

公开(公告)日：2021-04-29

申请号：US16768871

申请日：2018-12-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  ALLIED—BRISTOL LIFE SCIENCES, LLC

Inventor： Pravin Shirude ,  Ashit Ganguly ,  Ramakanth Sarabu

IPC: C07D471/04 ,  C07D401/06

Abstract: Disclosed are compounds of Formula (I), and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutically compositions thereof as well as methods for using the compounds in treating a variety of diseases such as, for example, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angiogenesis, ischemic damage, inflammatory diseases, cancers, musculoskeletal diseases, cardiovascular diseases, transplant rejection, multiple sclerosis, systemic sclerosis and neurodegenerative diseases.

公开(公告)号：US20210163443A1

公开(公告)日：2021-06-03

申请号：US17108024

申请日：2020-12-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Pravin Sudhakar Shirude ,  Satheesh Kesavan Nair ,  Ramesh Kumar Sistla ,  Ashit K. Ganguly ,  Ramakanth Sarabu

IPC: C07D401/06 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

Abstract: Disclosed are compounds of Formula I, and pharmaceutically acceptable salts thereof: Also disclosed are pharmaceutical compositions thereof as well as methods for using the compounds in treating a variety of diseases such as, for example, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angiogenesis, ischemic damage, inflammatory diseases, cancers, musculoskeletal diseases, cardiovascular diseases, transplant rejection, multiple sclerosis, systemic sclerosis and neurodegenerative diseases.