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公开(公告)号：US20160376371A1
公开(公告)日：2016-12-29
申请号：US15195098
申请日：2016-06-28
Applicant: The Rockefeller University , BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jeffrey V. Ravetch , Rony Dahan , Bryan C. Barnhart , Brigitte Devaux , Aaron P. Yamniuk , Shannon L. Okada , Brenda L. Stevens
IPC: C07K16/28
CPC classification number: C07K16/2878 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/72 , C07K2317/73 , C07K2317/75 , C07K2317/92
Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
Abstract translation: 本文提供了结合人CD40的激动性抗体或其抗原结合部分。 此类抗体任选地包含对FcγRIIb具有增强的特异性的Fc区。 本发明还提供了通过将本发明的抗体给予有需要的受试者来治疗癌症或慢性感染的方法。
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Patent Agency Ranking
公开(公告)号：US20190248911A1
公开(公告)日：2019-08-15
申请号：US16399379
申请日：2019-04-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Bryan C. Barnhart , Brigitte Devaux , Aaron P. Yamniuk , Shannon L. Okada , Brenda L. Stevens
CPC classification number: C07K16/2878 , A61K2039/505 , A61P31/12 , A61P35/00 , A61P35/02 , A61P35/04 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92 , C07K2317/94
Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
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公开(公告)号：US20200071412A1
公开(公告)日：2020-03-05
申请号：US16687107
申请日：2019-11-18
Applicant: The Rockefeller University , BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jeffrey V. Ravetch , Rony Dahan , Bryan C. Barnhart , Brigitte Devaux , Aaron P. Yamniuk , Shannon L. Okada , Brenda L. Stevens
IPC: C07K16/28
Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
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公开(公告)号：US11952427B2
公开(公告)日：2024-04-09
申请号：US17694890
申请日：2022-03-15
Applicant: Bristol-Myers Squibb Company , CytomX Therapeutics, Inc.
Inventor： Bryan C. Barnhart , Brigitte Devaux , Aaron P. Yamniuk , Shannon L. Okada , Brenda L. Stevens , James William West
CPC classification number: C07K16/2878 , C12N15/63 , C07K2317/56
Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
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公开(公告)号：US11306149B2
公开(公告)日：2022-04-19
申请号：US16958563
申请日：2018-12-27
Applicant: Bristol-Myers Squibb Company , CytomX Therapeutics, Inc.
Inventor： Bryan C. Barnhart , Brigitte Devaux , Aaron P. Yamniuk , Shannon L. Okada , Brenda L. Stevens , James William West
Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
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公开(公告)号：US10479838B2
公开(公告)日：2019-11-19
申请号：US15195098
申请日：2016-06-28
Applicant: The Rockefeller University , BRISTOL-MYERS SQUIBB COMPANY
Inventor： Jeffrey V. Ravetch , Rony Dahan , Bryan C. Barnhart , Brigitte Devaux , Aaron P. Yamniuk , Shannon L. Okada , Brenda L. Stevens
IPC: A61K39/395 , C07K16/28 , A61K39/00
Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
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