公开(公告)号：US09604964B2

公开(公告)日：2017-03-28

申请号：US14442670

申请日：2013-11-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Bruce A. Ellsworth ,  Jun Shi ,  William R. Ewing ,  Elizabeth A. Jurica ,  Andres S. Hernandez ,  Ximao Wu ,  Zhengxiang Gu ,  Zhenqiu Hong ,  Stephen P. O'Connor

IPC: C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D417/14 ,  C07D403/12 ,  C07D451/06 ,  A61K45/06 ,  A61K31/4545 ,  A61K31/4155 ,  C07D413/14 ,  C07D401/10 ,  C07D487/08 ,  A61K31/454 ,  A61K31/46 ,  A61K31/497 ,  A61K31/506 ,  A61K31/55 ,  C07D471/08

CPC classification number: C07D401/12 ,  A61K31/4155 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/497 ,  A61K31/506 ,  A61K31/55 ,  A61K45/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D451/06 ,  C07D471/08 ,  C07D487/08

Abstract: The present invention provides compounds of Formula (I): (Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

公开(公告)号：US20160297797A1

公开(公告)日：2016-10-13

申请号：US14442670

申请日：2013-11-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Bruce A. Ellsworth ,  Jun Shi ,  William R. Ewing ,  Elizabeth A. Jurica ,  Andres S. Hernandez ,  Ximao Wu ,  Zhengxiang Gu ,  Zhenqiu Hong ,  Stephen P. O'Connor

IPC: C07D401/12 ,  A61K31/454 ,  C07D451/06 ,  A61K31/46 ,  C07D405/14 ,  C07D401/14 ,  A61K31/506 ,  C07D417/14 ,  C07D403/12 ,  A61K31/55 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/4155 ,  C07D471/08 ,  C07D413/14 ,  A61K45/06

CPC classification number: C07D401/12 ,  A61K31/4155 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/497 ,  A61K31/506 ,  A61K31/55 ,  A61K45/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D451/06 ,  C07D471/08 ,  C07D487/08

Abstract: The present invention provides compounds of Formula (I): (Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.