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公开(公告)号：US10717725B2
公开(公告)日：2020-07-21
申请号：US16211848
申请日：2018-12-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Elizabeth Anne Jurica , Zhenqiu Hong
IPC: C07D401/14 , C07D401/12 , A61K31/506 , A61K31/4545 , A61K45/06 , A61K31/454
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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公开(公告)号：US20160297797A1
公开(公告)日：2016-10-13
申请号：US14442670
申请日：2013-11-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Bruce A. Ellsworth , Jun Shi , William R. Ewing , Elizabeth A. Jurica , Andres S. Hernandez , Ximao Wu , Zhengxiang Gu , Zhenqiu Hong , Stephen P. O'Connor
IPC: C07D401/12 , A61K31/454 , C07D451/06 , A61K31/46 , C07D405/14 , C07D401/14 , A61K31/506 , C07D417/14 , C07D403/12 , A61K31/55 , A61K31/4545 , A61K31/497 , A61K31/4155 , C07D471/08 , C07D413/14 , A61K45/06
CPC classification number: C07D401/12 , A61K31/4155 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/497 , A61K31/506 , A61K31/55 , A61K45/06 , C07D401/10 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D451/06 , C07D471/08 , C07D487/08
Abstract: The present invention provides compounds of Formula (I): (Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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公开(公告)号：US20150322044A1
公开(公告)日：2015-11-12
申请号：US14705524
申请日：2015-05-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Elizabeth A. Jurica , Zhenqiu Hong
IPC: C07D401/14 , A61K31/506 , C07D401/12 , A61K31/454 , A61K31/4545 , A61K45/06
CPC classification number: C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K45/06 , C07D401/12
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
Abstract translation: 本发明提供式（I）的化合物或其立体异构体，互变异构体，药学上可接受的盐，多晶型物或溶剂化物，其中所有变量如本文所定义。 这些化合物是可用作药物的GPR40G蛋白偶联受体调节剂。
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Patent Agency Ranking
公开(公告)号：US20180099949A1
公开(公告)日：2018-04-12
申请号：US15840198
申请日：2017-12-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Elizabeth A. Jurica , Zhenqiu Hong
IPC: C07D401/14 , C07D401/12 , A61K31/4545 , A61K31/454 , A61K45/06 , A61K31/506
CPC classification number: C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K45/06 , C07D401/12
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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公开(公告)号：US20200299267A1
公开(公告)日：2020-09-24
申请号：US16895058
申请日：2020-06-08
Applicant: Bristol-Myers Squibb Company
Inventor： ELIZABETH ANNE JURICA , Zhenqiu Hong
IPC: C07D401/14 , A61K31/4545 , A61K45/06 , A61K31/454 , A61K31/506 , C07D401/12
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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公开(公告)号：US20190112293A1
公开(公告)日：2019-04-18
申请号：US16211848
申请日：2018-12-06
Applicant: Bristol-Myers Squibb Company
Inventor： ELIZABETH ANNE JURICA , Zhenqiu Hong
IPC: C07D401/14 , C07D401/12 , A61K31/506 , A61K31/4545 , A61K45/06 , A61K31/454
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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公开(公告)号：US09873679B2
公开(公告)日：2018-01-23
申请号：US14705524
申请日：2015-05-06
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Elizabeth A. Jurica , Zhenqiu Hong
IPC: A61K31/505 , C07D401/14 , A61K31/4545 , A61K45/06 , A61K31/454 , A61K31/506 , C07D401/12
CPC classification number: C07D401/14 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K45/06 , C07D401/12
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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公开(公告)号：US09604964B2
公开(公告)日：2017-03-28
申请号：US14442670
申请日：2013-11-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Bruce A. Ellsworth , Jun Shi , William R. Ewing , Elizabeth A. Jurica , Andres S. Hernandez , Ximao Wu , Zhengxiang Gu , Zhenqiu Hong , Stephen P. O'Connor
IPC: C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D417/14 , C07D403/12 , C07D451/06 , A61K45/06 , A61K31/4545 , A61K31/4155 , C07D413/14 , C07D401/10 , C07D487/08 , A61K31/454 , A61K31/46 , A61K31/497 , A61K31/506 , A61K31/55 , C07D471/08
CPC classification number: C07D401/12 , A61K31/4155 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/497 , A61K31/506 , A61K31/55 , A61K45/06 , C07D401/10 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D451/06 , C07D471/08 , C07D487/08
Abstract: The present invention provides compounds of Formula (I): (Formula (I), or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.
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