公开(公告)号：US10562887B2

公开(公告)日：2020-02-18

申请号：US16098978

申请日：2017-05-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Natesan Murugesan ,  Peter W. Glunz ,  Mandar Shrikrishna Bodas ,  Navnath Dnyanoba Yadav ,  Venu Alla

IPC: C07D403/10 ,  C07D401/10 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

公开(公告)号：US20190152956A1

公开(公告)日：2019-05-23

申请号：US16098978

申请日：2017-05-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Natesan Murugesan ,  Peter W. Glunz ,  Mandar Shrikrishna Bodas ,  Navnath Dnyanoba Yadav ,  Venu Alla

IPC: C07D403/10 ,  C07D403/14 ,  C07D401/10 ,  C07D487/04 ,  C07D471/04

CPC classification number: C07D403/10 ,  C07D401/10 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.