公开(公告)号：US3780058A

公开(公告)日：1973-12-18

申请号：US3780058D

申请日：1971-09-16

申请人： BRZOZOWSKI Z ,  ANGIELSKI S ,  WOJCIKOWSKI C

发明人： BRZOZOWSKI Z ,  ANGIELSKI S ,  WOJCIKOWSKI C

IPC分类号： C07D231/06 ,  C07D49/10

CPC分类号： C07D231/06 ,  Y10S514/866

摘要： 2-PYRAZOLINE-1-CARBOXAMIDE SULFONAMIDE DERIVATIVES HAVING THE GENERAL FORMULA:

(3-R,4-R1,5-R2,5-R3-2-PYRAZOLIN-1-YL)-CO-NH-SO2-(1,4-

PHENYLENE)-Z

IN WHICH Z IS HYDROGEN, HALOGEN OR LOWER ALKYL, AND R, R1, R2, R3 ARE EACH HYDROGEN OR LOWER ALKYL. THESE SULFONAMIDE COMPOUNDS HAVE A HYPOGLYCEMIC EFFECT AND ARE OBTAINED BY REACTING A 2-PYRAZOLINE DERIVATIVES SUCH AS HN-CR2R3-CHR1-CR=N WITH AN ARYLSULFONYLUREA SUCH AS Z-C2H4EO2NHCONH2 OR WITH AN ARYLSULFONYLISOCYANATE SUCH AS Z-C6H4SO2NCO OR BY THE THERMAL DECOMPOSITION OF THE MOLECULAR COMBINATION OF THE 2PYRAZOLINE DERIVATIVE AND THE ARYSULFONYLUREA.