摘要:
Substituted pyrazolyl phenylacetic acid derivatives, e.g. 2pyrazolin-3-yl and pyrazol-3-yl-phenyl acetic acids and phenyl acetamides are prepared by reacting a crotonoyl or cinnamoyl phenylacetic acid derivative with a substituted hydrazine and are useful by reason of their pharmacological activity in animals, e.g. as anti-inflammatories.
摘要:
NOVEL OPTICAL BRIGHTENING AGENTS FOR THE TREATMENT OF FIBROUS MATERIALS AND FILMS, PROCESSES FOR THEIR USE AND DETERGENT COMPOSITIONS CONTAINING THEM.
WHEREIN A1 AND A2, INDEPENDENTLY, ARE ALKYLENE OF 1 TO 3 CARBON ATOMS, X IS -O- OR
>N-R10
WHEREIN R10 IS HYDROGEN OR LOWER ALKYL, R1 IS HYDROGEN OR SUBSTITUTED OR UNSUBSTITUTED ALKYL, R2 IS SUBSTITUTED OR UNSUBSTITUTED ALKYL, CYCLOHEXYL, METHYLCYCLOHEXYL, OR SUBSTITUTED OR UNSUBSTITUTED PHENYL, OR WHEN X SIGNIFIES
>N-R10
R2 AND R10 TOGETHER WITH A2 AND THE TWO ATTACHED NITROGENS FORM A PIPERAZINE RING, R3 IS SUBSTITUTED OR UNSUBSTITUTED ALKYL, OR R2 AND R5 TOGETHER WITH THE NITROGEN ATOM FORM A PIPERIDINE OR MORPHOLINE RING, R4 AND R5 ARE, INDEPENDENTLY, HYDROGEN, HALOGEN, SUBSTITUTED OR UNSUBSTITUTED ALKYL, OR ALKOXY, R6 IS HYDROGEN, SUBSTITUTED OR UNSUBSTITUTED ALKYL OR SUBSTITUTED OR UNSUBSTITUTED PHENYL, R7, R8 AND R9 ARE, INDEPENDENTLY, HYDROGEN; HALOGEN; SUBSTITUTED OR UNSUBSTITUTED ALKYL, ALKYLSULPHONYL, ALKYLTHIO, OR PHENYL; ALKOXY; CYANO; CARBOXYLIC OR SULPONIC ACID AMIDE OR ESTER; OR ACYLAMINO; N IS 1 OR 2, AND ANION $ SIGNIFIES AN EQUIVALENT OF A NON-CHROMOPHORIC ANION PROVIDED THAT IN THE FOREGOING DEFINITIONS ANY ALKYL MOIETY CONTAINS 1 TO 8 CARBON ATOMS UNLESS OTHERWISE SPECIFIED; ANY SUBSTITUENT ON SUBSTITUTED ALKYL OR ON THE ALKYL MOIETY OF ALKYLTHIO OR ALKYLSULPHONYL IS HALOGEN, PHENYL, PHENOXY, ALKOXY OR 1 TO 4 CARBON ATOMS, HYDROXYL OR CYANO, ANY SUBSTITUENT ON SUBSTITUTED PHENYL IS METHYL, CHLORO, OR METHOXY; ANY CARBOXYLIC OR SULPHONIC ACID ESTER IS AN ALKYL ESTER WHEREIN THE ALKYL GROUP CONTAINS 1 TO 5 CARBON ATOMS; ANY ACYL PORTON OF AN ACYLAMINO GROUP IS ALKONYL OF 1 TO 8 CARBON ATOMS OR ALKOXYCARBONYL OF 2 YO 9 CARBON ATOMS; BENZOYL; CHLORO- OR METHYLBENZOLY; PHENYLSULPHONYL, METHYLPHENYLSULPHONYL; METHYLSULPHONYL; OR ETHYLSULPHONYL, AND ANY HALOGEN IS CHLORO OR FLUORO.
IN WHICH Z IS HYDROGEN, HALOGEN OR LOWER ALKYL, AND R, R1, R2, R3 ARE EACH HYDROGEN OR LOWER ALKYL. THESE SULFONAMIDE COMPOUNDS HAVE A HYPOGLYCEMIC EFFECT AND ARE OBTAINED BY REACTING A 2-PYRAZOLINE DERIVATIVES SUCH AS HN-CR2R3-CHR1-CR=N WITH AN ARYLSULFONYLUREA SUCH AS Z-C2H4EO2NHCONH2 OR WITH AN ARYLSULFONYLISOCYANATE SUCH AS Z-C6H4SO2NCO OR BY THE THERMAL DECOMPOSITION OF THE MOLECULAR COMBINATION OF THE 2PYRAZOLINE DERIVATIVE AND THE ARYSULFONYLUREA.
摘要:
ALKYL SUBSTITUTED PYRROLES AND PYRAZOLINES ARE PREPARED BY TREATING A KETAZINE OR ALDAZINE WITH A METAL HALIDE OF THE FORMULA MX2 WHERE M IS COBALT OR NICKEL AND X IS A HALOGEN A TEMPERATURE OF 10 TO 300*C.
摘要:
The present invention provides compounds of the formula:
WHEREIN Ar represents an aromatic residue which may be substituted by substituents not having a chromophoric or anionic character, R1 and R2 represent alkyl groups containing one to five carbon atoms, which may be the same or different, n is 2 or 3 and X represents a monovalent anion or its equivalent. It also relates to the preparation of such compounds and to their use in optical brightening or whitening fibres based on polymers or copolymers of acrylonitrile.
摘要:
Alkyl substituted pyrroles and pyrazolines are prepared by treating a ketazine or aldazine with a metal halide of the formula MX2 where M is cobalt or nickel and X is a halogen at a temperature of 10* to 300* C.