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    Process for preparation of timosaponin B II
    1.
    发明授权
    Process for preparation of timosaponin B II 有权
    timosaponin B的制备方法II

    公开(公告)号：US08765925B2

    公开(公告)日：2014-07-01

    申请号：US11579101

    申请日：2005-04-21

    申请人： Baiping Ma ,  Hao Chen ,  Chengqi Xiong ,  Liping Kang ,  Jie Zhang

    发明人： Baiping Ma ,  Hao Chen ,  Chengqi Xiong ,  Liping Kang ,  Jie Zhang

    IPC分类号： C07H1/08 ,  C07H19/01 ,  C07J71/00

    CPC分类号： C07J71/00

    摘要： A method for preparation of Timosaponin BII, which uses Chinese traditional medicine Rhizoma Anemarrhenae or fresh rhizoma or fibrous root of Anemarrhena asphodeloides Bge. as raw material, and comprises isolation of Timosaponin BII by one or more processes selected from solvent extraction, resin adsorption, polyamide chromatography, reversed phase column chromatography, Sephadex LH-20 column chromatography, etc, combining with conventional drying method such as reduced pressure drying, freeze drying, spray drying, and so on. Timosaponin BII obtained by the present method is of over 90% purity, and the method is simple, practicable and suitable for industrial production.

    摘要翻译： 一种使用中药根茎或新鲜根茎或Anemarrhena asphodeloides Bge的纤维根的Timosaponin BII的制备方法。 作为原料，通过选自溶剂萃取，树脂吸附，聚酰胺色谱法，反相柱色谱法，Sephadex LH-20柱色谱法等一种或多种方法分离Timosaponin BII，结合常规干燥方法如减压干燥 ，冷冻干燥，喷雾干燥等。 本方法获得的Timosaponin BII纯度超过90％，方法简单，实用，适合工业生产。

    Process for Preparation of Timosaponin B II
    2.
    发明申请
    Process for Preparation of Timosaponin B II 有权
    Timosaponin B的制备方法II

    公开(公告)号：US20090012277A1

    公开(公告)日：2009-01-08

    申请号：US11579101

    申请日：2005-04-21

    申请人： Baiping Ma ,  Hao Chen ,  Chengqi Xiong ,  Liping Kang ,  Jie Zhang

    发明人： Baiping Ma ,  Hao Chen ,  Chengqi Xiong ,  Liping Kang ,  Jie Zhang

    IPC分类号： C07J17/00

    CPC分类号： C07J71/00

    摘要： A method for preparation of Timosaponin BII, which uses Chinese traditional medicine Rhizoma Anemarrhenae or fresh rhizoma or fibrous root of Anemarrhena asphodeloides Bge. as raw material, and comprises isolation of Timosaponin BII by one or more processes selected from solvent extraction, resin adsorption, polyamide chromatography, reversed phase column chromatography, Sephadex LH-20 column chromatography, etc, combining with conventional drying method such as reduced pressure drying, freeze drying, spray drying, and so on. Timosaponin BII obtained by the present method is of over 90% purity, and the method is simple, practicable and suitable for industrial production.

    摘要翻译： 一种使用中药根茎或新鲜根茎或Anemarrhena asphodeloides Bge的纤维根的Timosaponin BII的制备方法。 作为原料，通过选自溶剂萃取，树脂吸附，聚酰胺色谱法，反相柱色谱法，Sephadex LH-20柱色谱法等一种或多种方法分离Timosaponin BII，结合常规干燥方法如减压干燥 ，冷冻干燥，喷雾干燥等。 本方法获得的Timosaponin BII纯度超过90％，方法简单，实用，适合工业生产。

    PHARMACEUTICAL COMPOSITIONS FOR COMBATING THROMBOTIC DISEASES AND THEIR PREPARATION AND USES
    3.
    发明申请
    PHARMACEUTICAL COMPOSITIONS FOR COMBATING THROMBOTIC DISEASES AND THEIR PREPARATION AND USES 审中-公开
    用于治疗血栓形成疾病的药物组合物及其制备和用途

    公开(公告)号：US20120316122A1

    公开(公告)日：2012-12-13

    申请号：US13394375

    申请日：2009-09-07

    申请人： Baiping Ma ,  Yuwen Cong ,  Liping Kang ,  Yue Gao ,  Dawei Tan ,  Chengqi Xiong ,  Yang Zhao

    发明人： Baiping Ma ,  Yuwen Cong ,  Liping Kang ,  Yue Gao ,  Dawei Tan ,  Chengqi Xiong ,  Yang Zhao

    IPC分类号： A61K31/7048 ,  A61P9/10 ,  C12P33/20 ,  A61P11/00 ,  A61P9/00 ,  A61P7/02 ,  A61P3/10

    CPC分类号： A61K31/58 ,  A61K31/704 ,  A61K31/7048 ,  A61K36/8964 ,  A61K2300/00

    摘要： The present invention relates to a pharmaceutical composition for combating a thrombotic disease and a method for making the same and a use thereof. The pharmaceutical composition mainly comprises timosaponin AIII and timosaponin BII, and optionally pharmaceutically acceptable excipients, characterized in that the amount of timosaponin AIII is greater than or equal to the amount of timosaponin BII. The present invention further relates to a use of timosaponin AIII and timosaponin BII in manufacturing a medicament or product for the prophylaxis or to treatment of a thrombotic disease. The present pharmaceutical composition can not only bring about effects of prophylaxis or treatment of a thrombotic disease, but also alleviate blood bleeding or bleeding tendency in patients.

    摘要翻译： 本发明涉及一种抗血栓性疾病的药物组合物及其制备方法及其应用。 药物组合物主要包括timosaponin AIII和timosaponin BII，以及任选的药学上可接受的赋形剂，其特征在于Timosaponin AIII的量大于或等于timosaponin BII的量。 本发明还涉及timosaponin AIII和timosaponin BII在制备用于预防或治疗血栓形成疾病的药物或产品中的用途。 本发明的药物组合物不仅可以产生预防或治疗血栓形成疾病的效果，而且可以缓解患者的出血或出血倾向。