公开(公告)号：US20240240222A1

公开(公告)日：2024-07-18

申请号：US18562801

申请日：2022-06-27

申请人： Firmenich Incorporated

发明人： Chris Edano Noriega ,  Rama Rao Manam ,  Andrew P. Patron

IPC分类号： C12P33/20 ,  C12N9/10 ,  C12N9/24 ,  C12N15/66

CPC分类号： C12P33/20 ,  C12N9/1051 ,  C12N9/2402 ,  C12N15/66

摘要： Provided herein include methods of making mogroside compounds. e.g., siamenoside I 1, compositions (for example host cells) for making the mogroside compounds, and the mogroside compounds made by the methods disclosed herein, and compositions (for example, cell lysates) and recombinant cells comprising the mogroside compounds (e.g., siamenoside I). Also provided herein are novel cucurbitadienol synthases and the use thereof.

公开(公告)号：US20210002334A1

公开(公告)日：2021-01-07

申请号：US17026814

申请日：2020-09-21

申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

发明人： Ju Young LEE ,  In Seung JANG ,  Seohyun KIM ,  Sun-Chang KIM ,  Suk Chea JUNG ,  Jong Geon JEGAL

IPC分类号： C07K14/395 ,  C12P19/56 ,  C12P33/20 ,  C12N15/81

摘要： Provided are a recombinant yeast having improved ability to produce ginsenoside, which is prepared by overexpressing INO2 and INO4 or deleting OPT1 in a yeast having ability to produce ginsenoside, a method of preparing the yeast, and a method of producing ginsenoside by using the yeast.

公开(公告)号：US20200181671A1

公开(公告)日：2020-06-11

申请号：US16332196

申请日：2017-03-01

申请人： Guilin Layn Natural Ingredients Corp

发明人： Yunfei Song ,  Wenguo Yang ,  Yuanyuan Li ,  Meijin Guo ,  Jiarui Li ,  Zejian Wang ,  Yingping Zhuang

IPC分类号： C12P33/20 ,  C12N5/04

摘要： The present invention relates to a method for increasing the content of mogroside V in Siraitia grosvenorii suspended cells. In the method, 10-200 mg/L of a yeast inducer and 50-260 mg/L of methyl jasmonate are respectively added on days 5 to 11 of the culture cycle of Siraitia grosvenorii suspended cells, thereby increasing the synthesis rate and yield of mogroside V, and also reducing the amount of mogroside II secreted. The method is beneficial for the market-oriented and large-scale production and quality control management of mogroside V.

公开(公告)号：US10662458B2

公开(公告)日：2020-05-26

申请号：US15900557

申请日：2018-02-20

申请人： EVOLVA SA

发明人： Yaoquan Liu ,  Jorgen Hansen ,  Jens Houghton-Larsen ,  Muthuswamy Panchapagesa Murali ,  Sathish Kumar ,  Nina Nicoline Rasmussen

IPC分类号： C12P19/18 ,  C12P33/20 ,  C12N9/10 ,  C12P19/56 ,  C12P33/08 ,  C12N9/02 ,  C12N9/14 ,  C12N9/90 ,  C12P33/00 ,  C12P33/12 ,  C12N15/80

摘要： The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.

公开(公告)号：US10407706B2

公开(公告)日：2019-09-10

申请号：US15519326

申请日：2015-10-16

申请人： SUNTORY HOLDINGS LIMITED

发明人： Eiichiro Ono ,  Misa Ochiai

IPC分类号： C12P19/56 ,  C12P19/18 ,  C12P33/00 ,  C12P33/20 ,  C07J9/00 ,  C07J17/00

摘要： To provide a mogrol glycosyltransferase and a method for producing a mogrol glycoside using the enzyme. The present invention provides a mogrol glycosyltransferase and a method for producing a mogrol glycoside using the enzyme, and a transformant into which a mogrol glycosyltransferase gene is introduced and a method for preparing the transformant.

公开(公告)号：US20190048380A1

公开(公告)日：2019-02-14

申请号：US16057617

申请日：2018-08-07

申请人： INTELLIGENT SYNTHETIC BIOLOGY CENTER ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

发明人： Sun-Chang Kim ,  Ju Young Lee ,  In Seung Jang ,  Seohyun Kim ,  Jong Geon Jegal

IPC分类号： C12P33/20 ,  C07K14/415 ,  C12N9/88 ,  C12N9/02 ,  C12N9/04

摘要： The present invention relates to recombinant yeast, in which the productivity of ginsenoside is enhanced by overexpressing CPR5, PDI1, or ERO1 in yeast having the productivity of ginsenosides; a method for preparing the yeast; and a method for producing ginsenosides using the yeast.

公开(公告)号：US20180251806A1

公开(公告)日：2018-09-06

申请号：US15900557

申请日：2018-02-20

申请人： EVOLVA SA

发明人： Yaoquan Liu ,  Jorgen Hansen ,  Jens Houghton-Larsen ,  Muthuswamy Panchapagesa Murali ,  Sathish Kumar ,  Nina Nicoline Rasmussen

IPC分类号： C12P33/20 ,  C12N9/02 ,  C12P33/12 ,  C12P33/08 ,  C12P33/00 ,  C12P19/56 ,  C12P19/18 ,  C12N9/90 ,  C12N9/14 ,  C12N9/10 ,  C12N15/80

摘要： The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provided. Furthermore, the invention provides recombinant hosts useful in performing the methods of the invention.

公开(公告)号：US09796752B2

公开(公告)日：2017-10-24

申请号：US14778006

申请日：2014-03-18

申请人： Daiichi Sankyo Company, Limited

发明人： Satoshi Komoriya ,  Yasuhiro Nakagami ,  Emiko Hatano ,  Takashi Ohnuki ,  Kayoko Masuda ,  Mayumi Iizuka ,  Yasunori Ono

IPC分类号： C07J71/00 ,  C12R1/785 ,  C12P33/00 ,  C12P33/06 ,  C12R1/645 ,  C12P15/00 ,  C12P17/02 ,  C07J63/00 ,  C12N1/14 ,  C12P33/02 ,  C12P33/20

CPC分类号： C07J71/001 ,  C07J63/008 ,  C12N1/14 ,  C12P15/00 ,  C12P17/02 ,  C12P33/00 ,  C12P33/02 ,  C12P33/06 ,  C12P33/20 ,  C12R1/645 ,  C12R1/785

摘要： It is intended to provide a novel terpenoid derivative that exhibits anti-inflammatory action and a cytoprotective action by activating the Keap1/Nrf2/ARE signaling pathway. The present invention provides terpenoid derivative A represented by the following formula (I):

公开(公告)号：US08906647B2

公开(公告)日：2014-12-09

申请号：US12919008

申请日：2009-02-23

申请人： Michael Eissenstat ,  Dehui Duan

发明人： Michael Eissenstat ,  Dehui Duan

IPC分类号： C07D405/14 ,  C12P33/20 ,  G01N33/15 ,  C07D307/79 ,  C07D417/12 ,  C07D417/14 ,  C07D405/12 ,  C07D409/12 ,  C07D231/12 ,  C07D405/06

CPC分类号： C07D405/14 ,  A61K31/343 ,  A61K31/4155 ,  A61K31/443 ,  A61K45/06 ,  C07D231/12 ,  C07D307/79 ,  C07D307/81 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14 ,  Y10T436/14

摘要： Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.

摘要翻译： 提供抑制细胞色素P450酶的方法，其可用于通过防止细胞色素P450对药物或其它分子的降解来改善疾病的治疗。 提供的药物组合物可用作增效剂以改善药代动力学，增强生物利用度，并增强经细胞色素P450酶体内降解的药物的治疗效果。

公开(公告)号：US08263094B2

公开(公告)日：2012-09-11

申请号：US12236171

申请日：2008-09-23

申请人： Michael Fitzpatrick Wempe ,  Liu Deng ,  Stephanie Kay Clendennen ,  Neil Warren Boaz

发明人： Michael Fitzpatrick Wempe ,  Liu Deng ,  Stephanie Kay Clendennen ,  Neil Warren Boaz

IPC分类号： A61K8/02 ,  C12P33/20 ,  C07D487/00

CPC分类号： A61K31/22 ,  A61K31/23 ,  C07C67/08 ,  C07C69/95 ,  C07C2601/16

摘要： Esters of 4,5-disubstituted-oxy-2-methyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.

摘要翻译： 化学和/或酶促制备4,5-二取代 - 氧基-2-甲基-3,6-二氧代 - 环己-1,4-二烯基烷基酯的酯。 取决于酯，实现了改善的黑素细胞细胞毒性。 改进的细胞毒性特征与酯类似物与其相应的酸相比更具生理学相容性并且对皮肤刺激性较低。