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公开(公告)号:US06268473B1
公开(公告)日:2001-07-31
申请号:US09488799
申请日:2000-01-21
申请人: Baldomero M. Olivera , Richard T. Layer , Maren Watkins , David R. Hillyard , J. Michael McIntosh , Robert Schoenfeld , Robert M. Jones
发明人: Baldomero M. Olivera , Richard T. Layer , Maren Watkins , David R. Hillyard , J. Michael McIntosh , Robert Schoenfeld , Robert M. Jones
IPC分类号: C07K708
CPC分类号: C07K14/43504 , A61K38/00
摘要: The invention relates to relatively short peptides (termed &agr;-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The &agr;-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.
摘要翻译: 本发明涉及相对短的肽(本文中称为α-芋螺毒素),长度约10-25个残基,其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽,并且其优选包括两个 二硫键。 如本文所述,α-蛇毒毒素可用作神经肌肉阻滞剂,例如肌肉松弛剂。
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公开(公告)号:US20060247173A1
公开(公告)日:2006-11-02
申请号:US11482148
申请日:2006-07-07
申请人: Baldomero Olivera , Richard Layer , Maren Watkins , David Hillyard , J. McIntosh , Robert Schoenfeld , Jacob Nielsen , Robert Jones
发明人: Baldomero Olivera , Richard Layer , Maren Watkins , David Hillyard , J. McIntosh , Robert Schoenfeld , Jacob Nielsen , Robert Jones
IPC分类号: A61K38/17 , C07K14/435
CPC分类号: C07K14/435 , A61K38/00 , C07K14/43504
摘要: The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The α-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.
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公开(公告)号:US20050214213A1
公开(公告)日:2005-09-29
申请号:US11097315
申请日:2005-04-04
申请人: Baldomero Olivera , J. McIntosh , Maren Watkins , James Garrett , Lourdes Cruz , Michelle Grilley , Robert Schoenfeld , Craig Walker , Reshma Shetty , Robert Jones
发明人: Baldomero Olivera , J. McIntosh , Maren Watkins , James Garrett , Lourdes Cruz , Michelle Grilley , Robert Schoenfeld , Craig Walker , Reshma Shetty , Robert Jones
IPC分类号: A61K38/00 , C07K14/435 , C12N5/02 , A61K51/00 , A61K38/16
CPC分类号: C07K14/43504 , A61K38/00
摘要: The present invention is directed to conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, voltage-gated ligand channels and/or receptors. The invention is further directed to nucleic acid sequences encoding the conotoxin peptides and encoding propeptides, as well as the propeptides.
摘要翻译: 本发明涉及芋螺毒素肽,其衍生物或药学上可接受的盐。 本发明进一步涉及该肽,其衍生物和其药学上可接受的盐在治疗与电压门控离子通道,电压门控配体通道和/或受体相关的病症中的用途。 本发明还涉及编码芋螺毒素肽和编码前肽以及前肽的核酸序列。
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