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    Contryphan peptides
    1.
    发明授权
    Contryphan peptides 失效
    对角han肽

    公开(公告)号：US6077934A

    公开(公告)日：2000-06-20

    申请号：US61026

    申请日：1998-04-16

    申请人： Richard Jacobsen ,  Elsie Jimenez ,  Lourdes J. Cruz ,  Baldomero M. Olivera ,  William R. Gray ,  Michelle Grilley ,  Maren Watkins ,  David R. Hillyard

    发明人： Richard Jacobsen ,  Elsie Jimenez ,  Lourdes J. Cruz ,  Baldomero M. Olivera ,  William R. Gray ,  Michelle Grilley ,  Maren Watkins ,  David R. Hillyard

    IPC分类号： A61K38/00 ,  C07K7/06 ,  C07K5/00

    CPC分类号： C07K7/06 ,  A61K38/00 ,  Y10S530/857

    摘要： The present invention is directed to contryphan peptides having 6-12 amino acids, preferably including one or more D-tryptophan or D-leucine residues. The peptides of the present invention are generically termed "contryphans," although the D-leucine containing contryphans are sometimes referred to as leu-contryphans. More specifically, the present invention is directed to contryphan peptides having the general formula Xaa.sub.1 -Cys-Xaa.sub.2 -Xaa.sub.3 -Xaa.sub.4 -Pro-Xaa.sub.5 -Cys (SEQ ID NO:1), wherein Xaa.sub.1, is any amino acid or des-Xaa.sub.1, Xaa.sub.2 is Pro, 4-trans-hydroxyproline or Val, Xaa.sub.3 is D-Trp, L-Trp, D-Leu or L-Leu, preferably D-Trp or D-Leu, Xaa.sub.4 is any amino acid and Xaa.sub.5 is Trp or Tyr. When the peptide contains Xaa.sub.1, it is preferably Gly, Glu, or Lys, most preferably Gly. When Xaa.sub.3 is D- or L-Trp, Xaa.sub.2 is preferably Pro or 4-trans-hydroxyproline. When Xaa.sub.3 is D- or L-Leu, Xaa.sub.2 is preferably Val. The carboxy terminus may contain a carboxyl or an amide, preferably an amide. The present invention is further directed to the specific contryphan peptides and propeptides as described herein. The present invention is also directed to nucleic acids encoding the contryphan peptides and their propeptides as described herein. The contryphans of the present invention are useful as anticonvulsant or neuroprotective agents.

    摘要翻译： 本发明涉及具有6-12个氨基酸的优选肽，优选包括一个或多个D-色氨酸或D-亮氨酸残基。 本发明的肽通常被称为“contryphans”，尽管含有D-亮氨酸的对应物有时被称为leu-contryphans。 更具体地，本发明涉及具有通式Xaa1-Cys-Xaa2-Xaa3-Xaa4-Pro-Xaa5-Cys（SEQ ID NO：1）的反式肽，其中Xaa1是任何氨基酸或des-Xaa1， Xaa2是Pro，4-反 - 羟脯氨酸或Val，Xaa3是D-Trp，L-Trp，D-Leu或L-Leu，优选D-Trp或D-Leu，Xaa4是任何氨基酸，Xaa5是Trp或Tyr 。 当肽含有Xaa1时，其优选为Gly，Glu或Lys，最优选为Gly。 当Xaa3为D-或L-Trp时，Xaa2优选为Pro或4-反式 - 羟脯氨酸。 当Xaa3为D-或L-Leu时，Xaa2优选为Val。 羧基末端可以含有羧基或酰胺，优选酰胺。 本发明进一步针对如本文所述的特异性抗原肽和前肽。 本发明还涉及编码本文所述的敌百虫肽及其前肽的核酸。 本发明的对策可用作抗惊厥药或神经保护剂。

    Contryphan peptides
    2.
    发明授权
    Contryphan peptides 有权
    对角han肽

    公开(公告)号：US6153738A

    公开(公告)日：2000-11-28

    申请号：US466138

    申请日：1999-12-21

    申请人： Richard Jacobsen ,  Elsie Jimenez ,  Lourdes J. Cruz ,  Baldomero M. Olivera ,  William R. Gray ,  Michelle Grilley ,  Maren Watkins ,  David R. Hillyard

    发明人： Richard Jacobsen ,  Elsie Jimenez ,  Lourdes J. Cruz ,  Baldomero M. Olivera ,  William R. Gray ,  Michelle Grilley ,  Maren Watkins ,  David R. Hillyard

    IPC分类号： A61K38/00 ,  C07K7/06 ,  C07H21/04

    CPC分类号： C07K7/06 ,  A61K38/00 ,  Y10S530/857

    摘要： The present invention is directed to contryphan peptides having 6-12 amino acids, preferably including one or more D-tryptophan or D-leucine residues. The peptides of the present invention are generically termed "contryphans," although the D-leucine containing contryphans are sometimes referred to as leu-contryphans. More specifically, the present invention is directed to contryphan peptides having the general formula Xaa.sub.1 -Cys-Xaa.sub.2 -Xaa.sub.3 -Xaa.sub.4 -Pro-Xaa.sub.5 -Cys (SEQ ID NO:1), wherein Xaa.sub.1 is any amino acid or des-Xaa.sub.1, Xaa.sub.2 is Pro, 4-trans-hydroxyproline or Val, Xaa.sub.3 is D-Trp, L-Trp, D-Leu or L-Leu, preferably D-Trp or D-Leu, Xaa.sub.4 is any amino acid and Xaa.sub.5 is Trp or Tyr. When the peptide contains Xaa.sub.1, it is preferably Gly, Glu, or Lys, most preferably Gly. When Xaa.sub.3 is D- or L-Trp, Xaa.sub.2 is preferably Pro or 4-trans-hydroxyproline. When Xaa.sub.3 is D- or L-Leu, Xaa.sub.2 is preferably Val. The carboxy terminus may contain a carboxyl or an amide, preferably an amide. The present invention is further directed to the specific contryphan peptides and propeptides as described herein. The present invention is also directed to nucleic acids encoding the contryphan peptides and their propeptides as described herein. The contryphans of the present invention are useful as anticonvulsant or neuroprotective agents.

    摘要翻译： 本发明涉及具有6-12个氨基酸的优选肽，优选包括一个或多个D-色氨酸或D-亮氨酸残基。 本发明的肽通常被称为“contryphans”，尽管含有D-亮氨酸的对应物有时被称为leu-contryphans。 更具体地说，本发明涉及具有通式Xaa1-Cys-Xaa2-Xaa3-Xaa4-Pro-Xaa5-Cys（SEQ ID NO：1）的反式肽，其中Xaa1是任何氨基酸或des-Xaa1，Xaa2 是Pro，4-反式 - 羟基脯氨酸或Val，Xaa3是D-Trp，L-Trp，D-Leu或L-Leu，优选D-Trp或D-Leu，Xaa4是任何氨基酸，Xaa5是Trp或Tyr。 当肽含有Xaa1时，其优选为Gly，Glu或Lys，最优选为Gly。 当Xaa3为D-或L-Trp时，Xaa2优选为Pro或4-反式 - 羟脯氨酸。 当Xaa3为D-或L-Leu时，Xaa2优选为Val。 羧基末端可以含有羧基或酰胺，优选酰胺。 本发明进一步针对如本文所述的特异性抗原肽和前肽。 本发明还涉及编码本文所述的敌百虫肽及其前肽的核酸。 本发明的对策可用作抗惊厥药或神经保护剂。

    Conotoxin peptide PVIIA
    3.
    发明授权
    Conotoxin peptide PVIIA 失效
    芋螺毒素肽PVIIA

    公开(公告)号：US5672682A

    公开(公告)日：1997-09-30

    申请号：US619936

    申请日：1996-03-18

    申请人： Heinrich Terlau ,  Ki-Joon Shon ,  Michelle Grilley ,  Baldomero M. Olivera

    发明人： Heinrich Terlau ,  Ki-Joon Shon ,  Michelle Grilley ,  Baldomero M. Olivera

    IPC分类号： A61K38/00 ,  C07K14/435 ,  C07K14/00

    CPC分类号： C07K14/43504 ,  A61K38/00

    摘要： A new peptide, .kappa.-conotoxin PVIIA, is disclosed. This peptide is found naturally in the cone snail Conus purpurascens and has the amino acid sequence Cys-Arg-Ile-Xaa-Asn-Gln-Lys-Cys-Phe-Gln-His-Leu-Asp-Asp-Cys-Cys-Ser-Arg-Lys-Cys-Asn-Arg-Phe-Asn-Lys-Cys-Val (SEQ ID NO:1) where Xaa represents 4-trans-hydroxyproline hydroxyproline or proline. This peptide together with a previously disclosed peptide, .delta.-conotoxin PVIA, act synergistically to rapidly immobilize fish which are injected with the two peptides. Injection of .kappa.-conotoxin PVIIA alone results in different symptoms with an injected fish becoming hyperactive and then contracting and suddenly extending all major fins. This "fin-popping" occurs repeatedly resulting in a series of jerky movements, but injection of only .kappa.-conotoxin PVIIA does not immobilize or kill the fish.

    摘要翻译： 公开了一种新的肽，κ-毒素PVIIA。 这种肽天然存在于锥螺旋锥体中，具有氨基酸序列Cys-Arg-Ile-Xaa-Asn-Gln-Lys-Cys-Phe-Gln-His-Leu-Asp-Asp-Cys-Cys-Ser -Arg-Lys-Cys-Asn-Arg-Phe-Asn-Lys-Cys-Val（SEQ ID NO：1），其中Xaa表示4-反式 - 羟脯氨酸羟脯氨酸或脯氨酸。 该肽与先前公开的肽δ-毒素PVIA一起协同作用以快速固定注射了两种肽的鱼。 单独注射κ-毒素PVIIA导致不同的症状，注射的鱼变得活跃，然后收缩并突然延伸所有主要鳍。 这种“昙花一现”反复发生，导致一连串的剧烈运动，但只注射κ-毒素PVIIA不会使鱼类不能固定或杀死。