公开(公告)号：US07750158B2

公开(公告)日：2010-07-06

申请号：US11157510

申请日：2005-06-21

申请人： Bandarpalle B. Shankar ,  Eric Gilbert ,  Razia K. Rizvi ,  Chunli Huang ,  Joseph A. Kozlowski ,  Stuart McCombie ,  Neng-Yang Shih

发明人： Bandarpalle B. Shankar ,  Eric Gilbert ,  Razia K. Rizvi ,  Chunli Huang ,  Joseph A. Kozlowski ,  Stuart McCombie ,  Neng-Yang Shih

IPC分类号： C07D221/00 ,  A61K31/44

CPC分类号： C07D221/20 ,  C07D209/52 ,  C07D401/12 ,  C07D471/08

摘要： Compounds of Formula I: and/or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions containing such compounds exhibit anti-inflammatory and immunomodulatory activity, and can be effective in treating cancer and inflammatory, immunomodulatory or respiratory diseases or conditions.

摘要翻译： 式I化合物和/或其药学上可接受的盐，溶剂化物或前药，或含有这些化合物的药物组合物表现出抗炎和免疫调节活性，并且可有效治疗癌症和炎症，免疫调节或呼吸系统疾病或病症。

公开(公告)号：US20060100228A1

公开(公告)日：2006-05-11

申请号：US11157510

申请日：2005-06-21

申请人： Bandarpalle Shankar ,  Eric Gilbert ,  Razia Rizvi ,  Chunli Huang ,  Joseph Kozlowski ,  Stuart McCombie ,  Neng-Yang Shih

发明人： Bandarpalle Shankar ,  Eric Gilbert ,  Razia Rizvi ,  Chunli Huang ,  Joseph Kozlowski ,  Stuart McCombie ,  Neng-Yang Shih

IPC分类号： A61K31/4747 ,  A61K31/46 ,  A61K31/405 ,  C07D455/02 ,  C07D403/02

CPC分类号： C07D221/20 ,  C07D209/52 ,  C07D401/12 ,  C07D471/08

摘要： Compounds of Formula I: and/or pharmaceutically acceptable salts, solvates or prodrugs thereof, or pharmaceutical compositions containing such compounds exhibit anti-inflammatory and immunomodulatory activity, and can be effective in treating cancer and inflammatory, immunomodulatory or respiratory diseases or conditions.

摘要翻译： 式I化合物和/或其药学上可接受的盐，溶剂化物或前药，或含有这些化合物的药物组合物表现出抗炎和免疫调节活性，并且可有效治疗癌症和炎症，免疫调节或呼吸系统疾病或病症。

公开(公告)号：US20070178452A1

公开(公告)日：2007-08-02

申请号：US10277951

申请日：2002-10-21

申请人： Pascal Bouffard ,  John Herrmann ,  Chunli Huang ,  Michael Jeffers ,  Jingfang Ju ,  Luca Rastelli ,  Juliette Shimkets ,  Jan Simons ,  Bruce Taillon

发明人： Pascal Bouffard ,  John Herrmann ,  Chunli Huang ,  Michael Jeffers ,  Jingfang Ju ,  Luca Rastelli ,  Juliette Shimkets ,  Jan Simons ,  Bruce Taillon

IPC分类号： C12Q1/68 ,  G06F19/00

CPC分类号： C12N15/1096 ,  C12Q2600/158 ,  G16B30/00

摘要： Disclosed is a method in which DNA sequences derived from microsome-associated mRNA sequences in a mixed sample or in an arrayed single sequence clone can be determined and classified without sequencing. The methods make use of information on the presence of carefully chosen target subsequences, typically of length from 4 to 8 base pairs, and preferably the length between target subsequences in a sample DNA sequence together with DNA sequence databases containing lists of sequences likely to be present in the sample to determine a sample sequence. The preferred method uses restriction endonucleases to recognize target subsequences and cut the sample sequence. Then carefully chosen recognition moieties are ligated to the cut fragments, the fragments amplified, and the experimental observation made. Polymerase chain reaction (PCR) is the preferred method of amplification. Another embodiment of the invention uses information on the presence or absence of carefully chosen target subsequences in a single sequence clone together with DNA sequence databases to determine the clone sequence. Computer implemented methods are provided to analyze the experimental results and to determine the sample sequences in question and to carefully choose target subsequences in order that experiments yield a maximum amount of information

摘要翻译： 公开了可以确定和分类来自混合样品或排列单序列克隆中的微粒体相关mRNA序列的DNA序列而不进行测序的方法。 这些方法利用关于精确选择的目标子序列的存在的信息，通常长度为4至8个碱基对，优选样品DNA序列中目标子序列之间的长度以及含有可能存在的序列的DNA序列数据库 在样品中确定样品序列。 优选的方法是使用限制性核酸内切酶识别目标子序列并切割样品序列。 然后仔细选择识别部分连接到切割片段，扩增片段，并进行实验观察。 聚合酶链反应（PCR）是优选的扩增方法。 本发明的另一个实施方案使用关于在单个序列克隆中与DNA序列数据库一起存在或不存在仔细选择的目标子序列的信息来确定克隆序列。 提供计算机实现的方法来分析实验结果并确定所讨论的样本序列，并仔细选择目标子序列，以便实验产生最大量的信息