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    Indole derivatives substituted with long-chain alcohols and medicaments containing them
    1.
    发明申请
    Indole derivatives substituted with long-chain alcohols and medicaments containing them 失效
    被长链醇取代的吲哚衍生物和含有它们的药物

    公开(公告)号：US20080234357A1

    公开(公告)日：2008-09-25

    申请号：US12132345

    申请日：2008-06-03

    申请人： Bang LUU ,  Djalil Coowar ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    发明人： Bang LUU ,  Djalil Coowar ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    IPC分类号： A61K31/404 ,  A61P35/00

    CPC分类号： C07D209/12

    摘要： Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.

    摘要翻译： 提供由下式（I）表示的吲哚长链醇或其水合物或异构体：其中R 1，R 2，R 2， > 3和R 4各自独立地表示氢原子，甲基，乙酰基或羟基，n表示0〜20的数。 以及含有该组合物的药物组合物。 吲哚长链醇（I）表现出优异的神经生长促进作用，以及有效的抗氧化和抗肿瘤作用，因此可用作脑疾病包括痴呆症和恶性肿瘤的预防和/或治疗剂 包括脑肿瘤。

    Indole derivatives substituted with long-chain alcolhols and medicaments containing them
    2.
    发明申请
    Indole derivatives substituted with long-chain alcolhols and medicaments containing them 失效
    用长链醇盐取代的吲哚衍生物和含有它们的药物

    公开(公告)号：US20050131053A1

    公开(公告)日：2005-06-16

    申请号：US10504484

    申请日：2002-02-13

    申请人： Bang Luu ,  Djalil Coowar ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    发明人： Bang Luu ,  Djalil Coowar ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    IPC分类号： C07D209/12 ,  A61K31/405 ,  C07D209/04

    CPC分类号： C07D209/12

    摘要： The invention relates to a flange coupling of two pipes, in particular the pipes of an exhaust system of a motor vehicle internal combustion engine. The coupling is characterized in that: each of the flanges is formed onto the corresponding pipe by the shaping of one of the pipe regions that form the respective flanges; a first of the two flanges is configured with a first connection pipe section, which engages radially in the interior of the second flange; a sealing ring is clamped between the flanges; the flanges are axially fixed by a clamping deice. The coupling is designed to be produced in an efficient manner, easy to mount and configured so that it functions reliably.

    摘要翻译： 本发明涉及两个管道，特别是机动车辆内燃机的排气系统的管道的法兰联接。 联轴器的特征在于：每个凸缘通过形成相应凸缘的一个管区形成在相应的管上; 两个凸缘中的第一个被构造成具有径向接合在第二凸缘内部的第一连接管段; 密封环夹在凸缘之间; 凸缘由夹紧芯轴向固定。 联轴器设计成能够以有效的方式生产，易于安装和配置，使其可靠运行。

    Indole derivatives substituted with long-chain alcohols and medicaments containing them
    3.
    发明授权
    Indole derivatives substituted with long-chain alcohols and medicaments containing them 失效
    被长链醇取代的吲哚衍生物和含有它们的药物

    公开(公告)号：US07902249B2

    公开(公告)日：2011-03-08

    申请号：US12132345

    申请日：2008-06-03

    申请人： Bang Luu ,  Djalil Coowar ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    发明人： Bang Luu ,  Djalil Coowar ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    IPC分类号： A61K31/404 ,  C07D209/04

    CPC分类号： C07D209/12

    摘要： Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number from 0 to 20; and a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.

    摘要翻译： 提供由下式（I）表示的吲哚长链醇或其水合物或异构体：其中R1，R2，R3和R4各自独立地表示氢原子，甲基，乙酰基或 羟基，n表示0〜20的数; 以及含有该组合物的药物组合物。 吲哚长链醇（I）表现出优异的神经生长促进作用，以及有效的抗氧化和抗肿瘤作用，因此可用作脑疾病包括痴呆症和恶性肿瘤的预防和/或治疗剂 包括脑肿瘤。

    Indole derivatives and drugs containing the same
    5.
    发明授权
    Indole derivatives and drugs containing the same 失效
    吲哚衍生物和含有相同的药物

    公开(公告)号：US07307098B2

    公开(公告)日：2007-12-11

    申请号：US10520136

    申请日：2003-07-22

    申请人： Bang Luu ,  Djalil Coowar ,  Ellane Mohier ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    发明人： Bang Luu ,  Djalil Coowar ,  Ellane Mohier ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    IPC分类号： A61K31/404 ,  C07D209/12

    CPC分类号： C07D209/12

    摘要： An indole derivative represented by the following general formula (1): wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents —(CH2)nOH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component, wherein the indole derivative (1) has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.

    摘要翻译： 由以下通式（1）表示的吲哚衍生物：其中R 1，R 2，R 3和R 3中的至少一个，R 3，R 3， 代表含有1至20个碳原子的烷氧基，R 1，R 2，R 3，R 3， R 4表示氢，含有1至6个碳原子的烷基，乙酰基或羟基; 并且X和Y中的任一个表示 - （CH 2 CH 2）n OH其中n是0至30的整数，X和Y中的另一个表示氢 原子; 或其盐; 以及用于促进含有这种吲哚衍生物或其盐作为有效成分的干细胞分化的药物和试剂，其中吲哚衍生物（1）具有诱导神经干细胞特异性分化为神经元的作用，该吲哚衍生物 作为由神经元的损失或退化引起的脑功能障碍或神经病变的预防或治疗药物是有用的。

    Indole derivatives and drugs containing the same
    6.
    发明申请
    Indole derivatives and drugs containing the same 失效
    吲哚衍生物和含有相同的药物

    公开(公告)号：US20050261357A1

    公开(公告)日：2005-11-24

    申请号：US10520136

    申请日：2003-07-22

    申请人： Bang Luu ,  Djalil Coowar ,  Ellane Mohier ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    发明人： Bang Luu ,  Djalil Coowar ,  Ellane Mohier ,  Masashi Yamada ,  Yukie Suma ,  Hiroto Suzuki

    IPC分类号： A61P25/00 ,  A61P25/28 ,  A61P43/00 ,  C07D209/12 ,  A61K31/404 ,  C07D209/04

    CPC分类号： C07D209/12

    摘要： An indole derivative represented by the following general formula (1): wherein at least one of R1, R2, R3, and R4 represents an alkoxy group containing 1 to 20 carbon atoms, and other groups of the R1, R2, R3, and R4 represent hydrogen, an alkyl group containing 1 to 6 carbon atoms, acetyl group, or hydroxyl group; and either one of X and Y represents —(CH2)n OH wherein n is an integer of 0 to 30, and the other one of the X and Y represents hydrogen atom; or a salt thereof; and a drug and an agent for promoting differentiation of a stem cell containing such indole derivative or its salt as an effective component. The indole derivative (1) of the present invention has action of inducing differentiation of neural stem cell specifically into a neuron, and this indole derivative is useful as a prophylactic or therapeutic drug for brain dysfunction or neuropathy caused by loss or degeneration of the neuron.

    摘要翻译： 由以下通式（1）表示的吲哚衍生物：其中R 1，R 2，R 3和R 3中的至少一个，R 3，R 3， 代表含有1至20个碳原子的烷氧基，R 1，R 2，R 3，R 3， R 4表示氢，含有1至6个碳原子的烷基，乙酰基或羟基; 并且X和Y中的任一个表示 - （CH 2 CH 2）n OH其中n是0至30的整数，X和Y中的另一个表示氢 原子; 或其盐; 以及用于促进含有这种吲哚衍生物或其盐作为有效成分的干细胞分化的药物和试剂。 本发明的吲哚衍生物（1）具有诱导神经干细胞特异性分化为神经元的作用，该吲哚衍生物可用作由神经元的丧失或退化引起的脑功能障碍或神经病变的预防或治疗药物。