公开(公告)号：US08003109B2

公开(公告)日：2011-08-23

申请号：US11882180

申请日：2007-07-31

申请人： Barbara Bottazzi ,  Martino Introna ,  Alberto Mantovani ,  Annunciata Vecchi

发明人： Barbara Bottazzi ,  Martino Introna ,  Alberto Mantovani ,  Annunciata Vecchi

IPC分类号： A61K39/00

CPC分类号： A61K38/1709 ,  A61K48/00 ,  C07K14/47 ,  C07K14/71 ,  Y02A50/481

摘要： Pharmaceutical compositions are described containing a long pentraxin PTX3, particularly human PTX3, for the therapy of infectious and inflammatory or tumor diseases; expression vectors containing cDNA coding for PTX3; recombinant host cells transfected with such vectors; a method for producing substantial amounts of PTX3 involving the culturing of such cells, and the use of said vectors in the gene therapy of tumors.

摘要翻译： 描述的药物组合物含有长的pentraxin PTX3，特别是人PTX3，用于治疗感染性和炎性或肿瘤疾病; 含有编码PTX3的cDNA的表达载体; 用这些载体转染的重组宿主细胞; 用于生产涉及培养这种细胞的大量PTX3的方法，以及所述载体在肿瘤基因治疗中的用途。

公开(公告)号：US06380162B1

公开(公告)日：2002-04-30

申请号：US09297369

申请日：1999-07-01

申请人： Marta Muzio ,  Martino Introna ,  Alberto Mantovani

发明人： Marta Muzio ,  Martino Introna ,  Alberto Mantovani

IPC分类号： A61K3810

CPC分类号： C07K14/54 ,  A61K38/00

摘要： The present invention relates to a peptide capable of binding to ICE and/or to enzymes of the ICE family, which peptide consists essentially of the amino acid sequence of SEQ ID NO:1 reported in the Sequence Listing, in which Xaa is selected between Asp and Ala, optionally containing one or more amino acids at its N-terminal and/or C-terminal end. It also relates to the use of the above peptide, for the preparation of pharmaceutical compositions active in pathologies requiring ICE inhibition and/or inhibition of enzymes of the ICE family.

摘要翻译： 本发明涉及能够结合ICE和/或ICE家族的酶的肽，该肽基本上由序列表中报道的SEQ ID NO：1的氨基酸序列组成，其中Xaa选自Asp 和Ala，任选在其N-末端和/或C-末端含有一个或多个氨基酸。 它还涉及上述肽用于制备在需要ICE抑制和/或抑制ICE家族酶的病态中活性的药物组合物的用途。

公开(公告)号：US20070014785A1

公开(公告)日：2007-01-18

申请号：US11498103

申请日：2006-08-03

申请人： Josee Golay ,  Martino Introna ,  Alessandro Rambaldi ,  Andrea Biondi

发明人： Josee Golay ,  Martino Introna ,  Alessandro Rambaldi ,  Andrea Biondi

IPC分类号： A61K39/395

CPC分类号： C07K16/2887 ,  A61K39/395 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2300/00

摘要： It is described the use of antibodies against exogenous surface antigens not present on normal human T lymphocytes for the preparation of compositions for the treatment of the graft versus host disease in patients who have received T lymphocytes transduced with such exogenous surface antigens.

摘要翻译： 描述了使用针对正常人T淋巴细胞上不存在的外源性表面抗原的抗体来制备用于治疗接受与外源性表面抗原转导的T淋巴细胞的移植物抗宿主病的组合物。