专利检索 ap:("Barbara Briggs" OR "James Kanter" OR "John J. G. Mullins" OR "Gerd Ruhter" OR "Uko Udodong" OR "Milton Zmijewski, Jr." OR "Daniel Verral, II") AND inv:"Daniel Verral, II" 第 1 页

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发明授权
Methods for producing chiral chromones, chromanes, amino substituted chromanes and intermediates therefor 有权

公开(公告)号：US06756403B2

公开(公告)日：2004-06-29

申请号：US10297096

申请日：2003-07-11

申请人： Barbara Briggs , James Kanter , John J. G. Mullins , Gerd Ruhter , Uko Udodong , Milton Zmijewski, Jr. , Daniel Verral, II

发明人： Barbara Briggs , James Kanter , John J. G. Mullins , Gerd Ruhter , Uko Udodong , Milton Zmijewski, Jr. , Daniel Verral, II

IPC分类号： A61K3135

CPC分类号： C07D311/74 , A61K31/353 , C07D311/22 , C07D311/24 , C07D311/58

摘要： Disclosed are process steps and novel processes for producing chromane compositions enriched in at least one (2R or 2S) enantiomer, preferably chroman-2-yl carboxylic acid compounds and chroman-2-yl carboxylic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are enzymatic processes for resolving chiral intermediates or final products to provide desired enantiomers.