公开(公告)号：US06855833B2

公开(公告)日：2005-02-15

申请号：US10296873

申请日：2001-06-01

申请人： James Kanter ,  John J. G. Mullins ,  Robert Scarborough ,  Derek Walker ,  Thomas Hense

发明人： James Kanter ,  John J. G. Mullins ,  Robert Scarborough ,  Derek Walker ,  Thomas Hense

IPC分类号： A61P7/00 ,  C07D311/20 ,  C07D311/22 ,  C07D311/58 ,  C07D311/66

CPC分类号： C07D311/22 ,  C07D311/20 ,  C07D311/58

摘要： Disclosed are processes for producing chromane compounds, preferably chroman-2-yl acetic acid compounds and 6-amino-chroman-2-yl acetic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors.

摘要翻译： 本发明公开了生产色氨酸化合物，优选苯并二氢吡喃-2-基乙酸化合物和6-氨基 - 苯并二氢吡喃-2-基乙酸酯的方法，其为制备血小板聚集抑制剂的中间体和/或本身是有效的血小板聚集抑制剂。

公开(公告)号：US06756403B2

公开(公告)日：2004-06-29

申请号：US10297096

申请日：2003-07-11

申请人： Barbara Briggs ,  James Kanter ,  John J. G. Mullins ,  Gerd Ruhter ,  Uko Udodong ,  Milton Zmijewski, Jr. ,  Daniel Verral, II

发明人： Barbara Briggs ,  James Kanter ,  John J. G. Mullins ,  Gerd Ruhter ,  Uko Udodong ,  Milton Zmijewski, Jr. ,  Daniel Verral, II

IPC分类号： A61K3135

CPC分类号： C07D311/74 ,  A61K31/353 ,  C07D311/22 ,  C07D311/24 ,  C07D311/58

摘要： Disclosed are process steps and novel processes for producing chromane compositions enriched in at least one (2R or 2S) enantiomer, preferably chroman-2-yl carboxylic acid compounds and chroman-2-yl carboxylic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are enzymatic processes for resolving chiral intermediates or final products to provide desired enantiomers.

公开(公告)号：US06903227B2

公开(公告)日：2005-06-07

申请号：US10297103

申请日：2001-06-01

申请人： James Kanter ,  John J. G. Mullins ,  Anjali Pandey ,  Robert Scarborough

发明人： James Kanter ,  John J. G. Mullins ,  Anjali Pandey ,  Robert Scarborough

IPC分类号： C07D311/22 ,  C07D311/58 ,  C12P17/06

CPC分类号： C07D311/58 ,  C07D311/22

摘要： Novel processes for producing enantiomerically enriched and enantiomerically pure compositions of 2-acyl substituted chromane compounds, and 2-acylchromane compounds that are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors are disclosed. Further disclosed are processes for producing salts such as acid addition salts for such enantiomerically enriched compositions.

摘要翻译： 公开了用于产生2-酰基取代的色烯化合物的对映体富集和对映体纯的组合物的新方法和作为制备血小板聚集抑制剂的中间体和/或本身是有效的血小板聚集抑制剂的2-酰基苯并二氢吡喃化合物。 进一步公开的是制备盐的方法，例如这种对映异构体富集的组合物的酸加成盐。