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12 条记录 (耗时 0.03 秒)

    TITRATION PACKAGE FOR NERAMEXANE AND ITS USE IN THE TREATMENT OF AN INNER EAR DISORDER
    2.
    发明申请
    TITRATION PACKAGE FOR NERAMEXANE AND ITS USE IN THE TREATMENT OF AN INNER EAR DISORDER 有权
    NERAMEXANE的治疗包及其用于治疗内耳病的药物

    公开(公告)号：US20100298441A1

    公开(公告)日：2010-11-25

    申请号：US12733645

    申请日：2008-09-10

    申请人： Barbara Ellers-Lenz ,  Tanja Rosenberg ,  Erhard Seiller ,  Hagen Kruger ,  Michael Althaus

    发明人： Barbara Ellers-Lenz ,  Tanja Rosenberg ,  Erhard Seiller ,  Hagen Kruger ,  Michael Althaus

    IPC分类号： A61K31/13 ,  A61P27/16

    CPC分类号： A61K31/13 ,  A61K9/2054 ,  A61K45/06

    摘要： The present invention relates to a titration scheme for the administration of a 1-amino-alkylcyclohexane derivative which allows for quick attainment of an effective dose of a 1-amino-alkylcyclohexane derivative while minimizing side effects. The present invention further relates to a titration package for providing a 1-amino-alkylcyclohexane derivative (e.g., neramexane or a pharmaceutically acceptable salt thereof) in at least two different dosages. The present titration scheme/titration package may be useful in the treatment of various diseases, including tinnitus.

    摘要翻译： 本发明涉及一种用于施用1-氨基 - 烷基环己烷衍生物的滴定方案，其允许快速获得有效剂量的1-氨基 - 烷基环己烷衍生物，同时尽量减少副作用。 本发明还涉及用于以至少两种不同剂量提供1-氨基 - 烷基环己烷衍生物（例如奈拉美生或其药学上可接受的盐）的滴定包装。 本滴定方案/滴定包可用于治疗各种疾病，包括耳鸣。

    Compositions Comprising Cyclohexylamines and Aminoadamantanes
    4.
    发明申请
    Compositions Comprising Cyclohexylamines and Aminoadamantanes 审中-公开
    包含环己胺和氨基金刚烷的组合物

    公开(公告)号：US20070270500A1

    公开(公告)日：2007-11-22

    申请号：US10578765

    申请日：2004-11-05

    申请人： Mahendra Dedhiya ,  Shashank Mahashabde ,  Yan Yang ,  Anshu Goel ,  Erhard Seiller ,  Bernhard Hauptmeier

    发明人： Mahendra Dedhiya ,  Shashank Mahashabde ,  Yan Yang ,  Anshu Goel ,  Erhard Seiller ,  Bernhard Hauptmeier

    IPC分类号： A61K31/136 ,  A61K31/13 ,  A61P25/00

    CPC分类号： A61K31/13 ,  A61K9/0063 ,  Y02A50/411

    摘要： The invention is directed to formulations of pharmaceutical compounds, such as the Cyclohexylamines and Aminoadamantanes which have antimicrobial properties. In particular, it is directed to aqueous based formulations with reduced amounts of preservatives which allow safe and convenient administration and flexible dosing and which, in the case of oral formulations, are easy to swallow. Optionally, the compositions contain components that provide the requisite stability and shelf life while reducing or avoiding incrustation of the composition around the container closure which leads to leaks and difficulty in opening the container.

    摘要翻译： 本发明涉及药物化合物的制剂，例如具有抗微生物性质的环己胺和氨基金刚烷。 特别地，其涉及具有减少量的防腐剂的含水基制剂，其允许安全和方便的施用和柔性给药，并且在口服制剂的情况下，易于吞咽。 任选地，组合物包含提供必要的稳定性和保质期的组分，同时减少或避免组合物围绕容器封闭物的结垢，这导致泄漏和难以打开容器。

    Mechanically-stable, readily-disintegratable tablets made of small preformed particles containing active ingredients
    8.
    发明授权
    Mechanically-stable, readily-disintegratable tablets made of small preformed particles containing active ingredients 失效
    机械稳定，容易崩解的片剂，由含有活性成分的小预成型颗粒制成

    公开(公告)号：US5288501A

    公开(公告)日：1994-02-22

    申请号：US905036

    申请日：1992-06-26

    申请人： Eberhard Nurnberg ,  Erhard Seiller ,  Bernd Kuhn

    发明人： Eberhard Nurnberg ,  Erhard Seiller ,  Bernd Kuhn

    IPC分类号： A61J3/06 ,  A61K9/14 ,  A61K9/20 ,  A61K9/32 ,  A61K9/36 ,  A61K9/50

    CPC分类号： A61K9/2095 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5078

    摘要： The application discloses a process for the manufacture of mechanically-stable, readily-disintegratable tablets made of small preformed, preferably rounded, particles or pellets containing a high percentage of active ingredient in which--prior to compression--the particles are coated with an aqueous or aqueous/organic suspension containing water-soluble polyvinyl alcohol having an ester content of 19.4 to 6.7%, a disintegrant, and finely-divided cellulose, the remainder being excipients such as additional colloids, adjuvants, dyes, and/or flavors and the suspending liquid, and dried, the stable but readily-friable tablet product thus-produced, and a method of delivering an active ingredient by the employment of such a tablet for oral ingestion.

    摘要翻译： 本申请公开了一种用于制造机械稳定的，易于崩解的片剂的方法，其由预先形成的，优选圆形的颗粒或丸粒制成，其含有高百分比的活性成分，其中 - 在压缩之前，将颗粒用水或 含有酯含量为19.4至6.7％的水溶性聚乙烯醇的水/有机悬浮液，崩解剂和细碎纤维素，其余为赋形剂，例如附加胶体，助剂，染料和/或香料，以及悬浮液 并干燥，如此生产的稳定但易碎的片剂，以及通过使用这种用于口服摄取的片剂递送活性成分的方法。

    COMPOSITIONS COMPRISING CYCLOHEXYLAMINES AND AMINOADAMANTANES
    10.
    发明申请
    COMPOSITIONS COMPRISING CYCLOHEXYLAMINES AND AMINOADAMANTANES 审中-公开
    包含环己基氨基甲酸酯和氨基琥珀酸酯的组合物

    公开(公告)号：US20120238631A1

    公开(公告)日：2012-09-20

    申请号：US13456751

    申请日：2012-04-26

    申请人： Mahendra G. Dedhiya ,  Shashank Mahashabde ,  Yan Yang ,  Anshu Goel ,  Erhard Seiller ,  Bernhard Hauptmeier

    发明人： Mahendra G. Dedhiya ,  Shashank Mahashabde ,  Yan Yang ,  Anshu Goel ,  Erhard Seiller ,  Bernhard Hauptmeier

    IPC分类号： A61K31/13 ,  A61P25/00 ,  A61P31/00

    CPC分类号： A61K31/13 ,  A61K9/0063 ,  Y02A50/411

    摘要： The invention is directed to formulations of pharmaceutical compounds, such as the Cyclohexylamines and Aminoadamantanes which have antimicrobial properties. In particular, it is directed to aqueous based formulations with reduced amounts of preservatives which allow safe and convenient administration and flexible dosing and which, in the case of oral formulations, are easy to swallow. Optionally, the compositions contain components that provide the requisite stability and shelf life while reducing or avoiding incrustation of the composition around the container closure which leads to leaks and difficulty in opening the container.

    摘要翻译： 本发明涉及药物化合物的制剂，例如具有抗微生物性质的环己胺和氨基金刚烷。 特别地，其涉及具有减少量的防腐剂的含水基制剂，其允许安全和方便的施用和柔性给药，并且在口服制剂的情况下，易于吞咽。 任选地，组合物包含提供必要的稳定性和保质期的组分，同时减少或避免组合物围绕容器封闭物的结垢，这导致泄漏和难以打开容器。