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公开(公告)号：US08465766B2
公开(公告)日：2013-06-18
申请号：US13236847
申请日：2011-09-20
申请人： Barbara Krug , Sven Dabek , Kai-Martin Mueller , Marco Rudolf , Christiane Ostermeyer , Hiltraut Pietsch
发明人： Barbara Krug , Sven Dabek , Kai-Martin Mueller , Marco Rudolf , Hanns Pietsch , Christiane Ostermeyer
IPC分类号： A61K9/66
CPC分类号： A01N31/02 , A01N43/40 , A01N2300/00
摘要： Aqueous wound and mucous membrane disinfectant containing a) octenidine dihydrochloride, and b) one or more active ingredients selected from the group ethanol, 1-propanol, 2-propanol, undecylene amidopropyl trimonium methosulfate, 3-(4-chlorophenoxy)-1,2-propanediol and/or sodium hydroxymethylglycinate and c) glycerin and/or 1,2-diols having 3 to 10 carbon atoms, and d) optionally surfactants, emulsifiers, solubilizers, pH regulators, dyestuffs, perfumes and/or thickeners, the agent being free of phenoxyethanol, phenoxypropanol, phenoxyisopropanol and organic acids.
摘要翻译： 含有a）奥氮平二盐酸盐的水性伤口和粘膜消毒剂，和b）一种或多种选自乙醇，1-丙醇，2-丙醇，十一烷基氨基丙基三甲基甲硫酸盐，3-（4-氯苯氧基）-1,2 - 丙二醇和/或羟甲基甘氨酸钠，和c）具有3-10个碳原子的甘油和/或1,2-二醇，和d）任选的表面活性剂，乳化剂，增溶剂，pH调节剂，染料，香料和/或增稠剂， 不含苯氧基乙醇，苯氧基丙醇，苯氧基异丙醇和有机酸。
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公开(公告)号：US20120070510A1
公开(公告)日：2012-03-22
申请号：US13236847
申请日：2011-09-20
申请人： BARBARA KRUG , Sven Dabek , Kai-Martin Mueller , Marco Rudolf , Hanns Pietsch , Hiltraut Pietsch , Christiane Ostermeyer
发明人： BARBARA KRUG , Sven Dabek , Kai-Martin Mueller , Marco Rudolf , Hanns Pietsch , Hiltraut Pietsch , Christiane Ostermeyer
CPC分类号： A01N31/02 , A01N43/40 , A01N2300/00
摘要： Aqueous wound and mucous membrane disinfectant containing a) octenidine dihydrochloride, and b) one or more active ingredients selected from the group ethanol, 1-propanol, 2-propanol, undecylene amidopropyl trimonium methosulfate, 3-(4-chlorophenoxy)-1,2-propanediol and/or sodium hydroxymethylglycinate and c) glycerin and/or 1,2-diols having 3 to 10 carbon atoms, and d) optionally surfactants, emulsifiers, solubilisers, pH regulators, dyestuffs, perfumes and/or thickeners, the agent being free of phenoxyethanol, phenoxypropanol, phenoxyisopropanol and organic acids.
摘要翻译： 含有a）奥氮平二盐酸盐的水性伤口和粘膜消毒剂，和b）一种或多种选自乙醇，1-丙醇，2-丙醇，十一烷基氨基丙基三甲基甲硫酸盐，3-（4-氯苯氧基）-1,2 丙二醇和/或羟甲基甘氨酸钠，和c）具有3-10个碳原子的甘油和/或1,2-二醇，和d）任选的表面活性剂，乳化剂，增溶剂，pH调节剂，染料，香料和/或增稠剂， 不含苯氧基乙醇，苯氧基丙醇，苯氧基异丙醇和有机酸。
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公开(公告)号：US20090076084A1
公开(公告)日：2009-03-19
申请号：US12064746
申请日：2006-07-31
申请人： Barbara Krug , Sven Dabek , Kai-Martin Mueller , Marco Rudolf , Hanns Pietsch , Hiltraut Pietsch , Christiane Ostermeyer
发明人： Barbara Krug , Sven Dabek , Kai-Martin Mueller , Marco Rudolf , Hanns Pietsch , Hiltraut Pietsch , Christiane Ostermeyer
CPC分类号： A01N31/02 , A01N43/40 , A01N2300/00
摘要： Aqueous wound and mucous membrane disinfectant containing a) octenidine dihydrochloride, and b) one or more active ingredients selected from the group ethanol, 1-propanol, 2-propanol, undecylene amidopropyl trimonium methosulfate, 3-(4-chlorophenoxy)-1,2-propanediol and/or sodium hydroxymethylglycinate and c) glycerin and/or 1,2-diols having 3 to 10 carbon atoms, and d) optionally surfactants, emulsifiers, solubilisers, pH regulators, dyestuffs, perfumes and/or thickeners, the agent being free of phenoxyethanol, phenoxypropanol, phenoxyisopropanol and organic acids.
摘要翻译： 含有a）奥氮平二盐酸盐的水性伤口和粘膜消毒剂，和b）一种或多种选自乙醇，1-丙醇，2-丙醇，十一烷基氨基丙基三甲基甲硫酸盐，3-（4-氯苯氧基）-1,2 丙二醇和/或羟甲基甘氨酸钠，和c）具有3-10个碳原子的甘油和/或1,2-二醇，和d）任选的表面活性剂，乳化剂，增溶剂，pH调节剂，染料，香料和/或增稠剂， 不含苯氧基乙醇，苯氧基丙醇，苯氧基异丙醇和有机酸。
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公开(公告)号：US5880099A
公开(公告)日：1999-03-09
申请号：US926831
申请日：1997-09-10
CPC分类号： A61K31/6615 , A61K31/683 , C07F9/117 , Y10S514/851
摘要： The present invention provides compositions that are cell permeable antagonists of inositol polyphosphates. In addition, the invention provides methods for enhancing chloride ion secretion from a cell by contacting the cells with cell permeable antagonists of inositol polyphosphates. The invention also provides methods for enhancing chloride ion secretion in an individual by administering cell permeable antagonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with cystic fibrosis in an individual by administering a cell permeable antagonist of inositol polyphosphates to the individual. The invention also provides compositions that are cell permeable agonists of inositol polyphosphates. In addition, the invention provides methods for decreasing chloride ion secretion from a cell by contacting the cell with cell permeable agonists of inositol polyphosphates. The invention also provides methods for decreasing chloride ion secretion in an individual by administering cell permeable agonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with secretory diarrhea in an individual by administering cell permeable agonists of inositol polyphosphates to the individual.
摘要翻译： 本发明提供了作为肌醇多磷酸盐的细胞渗透性拮抗剂的组合物。 此外，本发明提供了通过使细胞与肌醇多磷酸盐的细胞可渗透的拮抗剂接触来提高细胞中氯离子分泌的方法。 本发明还提供了通过向个体施用肌醇多磷酸盐的细胞可渗透的拮抗剂来增强个体中的氯离子分泌的方法。 本发明还提供了通过向个体施用肌醇多磷酸盐的细胞可渗透拮抗剂来减轻个体中与囊性纤维化相关的征兆或症状的方法。 本发明还提供了作为肌醇多磷酸盐的细胞渗透性激动剂的组合物。 此外，本发明提供了通过使细胞与肌醇多磷酸盐的细胞可渗透的激动剂接触来减少细胞中氯离子分泌的方法。 本发明还提供通过向个体施用肌醇多磷酸盐的细胞可渗透的激动剂来减少个体中的氯离子分泌的方法。 本发明另外提供了通过向个体施用肌醇多磷酸盐的细胞可渗透的激动剂来减轻个体中与分泌性腹泻相关的征兆或症状的方法。
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公开(公告)号：US20120208894A1
公开(公告)日：2012-08-16
申请号：US12405182
申请日：2009-03-16
申请人： Guenter Kampf , Claudia James , Sven Eggerstedt , Marco Rudolf
发明人： Guenter Kampf , Claudia James , Sven Eggerstedt , Marco Rudolf
CPC分类号： A61Q17/005 , A01N31/02 , A61K8/31 , A61K8/34 , A61K8/585
摘要： A multi-purpose hand disinfectant and in particular, a hand disinfectant which meets the FDA (Food and Drug Administration) requirements for use both as an antiseptic handwash or health-care personnel handwash drug product and as a surgical hand scrub drug product is described herein.
摘要翻译： 特别地，本文描述了多用途手消毒剂，特别是符合FDA（食品和药物管理局）要求用作防腐手洗或保健人员手洗药物产品和作为手术手洗药品的手消毒剂 。
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公开(公告)号：US5977078A
公开(公告)日：1999-11-02
申请号：US934450
申请日：1997-09-19
CPC分类号： A61K31/6615 , A61K31/683 , C07F9/117 , Y10S514/851
摘要： The present invention provides compositions that are cell permeable antagonists of inositol polyphosphates. In addition, the invention provides methods for enhancing chloride ion secretion from a cell by contacting the cells with cell permeable antagonists of inositol polyphosphates. The invention also provides methods for enhancing chloride ion secretion in an individual by administering cell permeable antagonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with cystic fibrosis in an individual by administering a cell permeable antagonist of inositol polyphosphates to the individual. The invention also provides compositions that are cell permeable agonists of inositol polyphosphates. In addition, the invention provides methods for decreasing chloride ion secretion from a cell by contacting the cell with cell permeable agonists of inositol polyphosphates. The invention also provides methods for decreasing chloride ion secretion in an individual by administering cell permeable agonists of inositol polyphosphates to the individual. The invention additionally provides methods for alleviating a sign or symptom associated with secretory diarrhea in an individual by administering cell permeable agonists of inositol polyphosphates to the individual.
摘要翻译： 本发明提供了作为肌醇多磷酸盐的细胞渗透性拮抗剂的组合物。 此外，本发明提供了通过使细胞与肌醇多磷酸盐的细胞可渗透的拮抗剂接触来提高细胞中氯离子分泌的方法。 本发明还提供了通过向个体施用肌醇多磷酸盐的细胞可渗透的拮抗剂来增强个体中的氯离子分泌的方法。 本发明还提供了通过向个体施用肌醇多磷酸盐的细胞可渗透拮抗剂来减轻个体中与囊性纤维化相关的征兆或症状的方法。 本发明还提供了作为肌醇多磷酸盐的细胞渗透性激动剂的组合物。 此外，本发明提供了通过使细胞与肌醇多磷酸盐的细胞可渗透的激动剂接触来减少细胞的氯离子分泌的方法。 本发明还提供通过向个体施用肌醇多磷酸盐的细胞可渗透的激动剂来减少个体中的氯离子分泌的方法。 本发明另外提供了通过向个体施用肌醇多磷酸盐的细胞可渗透的激动剂来减轻个体中与分泌性腹泻相关的征兆或症状的方法。
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