公开(公告)号：US08759008B2

公开(公告)日：2014-06-24

申请号：US12777837

申请日：2010-05-11

申请人： Basil I. Swanson ,  Aaron S. Anderson ,  Andrew M. Dattelbaum ,  Jurgen G. Schmidt

发明人： Basil I. Swanson ,  Aaron S. Anderson ,  Andrew M. Dattelbaum ,  Jurgen G. Schmidt

IPC分类号： G01N33/53

CPC分类号： G01N33/54393 ,  G01N33/551 ,  Y10T428/31663

摘要： The present invention provides a composite material including a substrate having an oxide surface, and, a continuous monolayer on the oxide surface, the monolayer including a silicon atom from a trifunctional alkyl/alkenyl/alkynyl silane group that attaches to the oxide surface, an alkyl/alkenyl/alkynyl portion of at least three carbon atoms, a polyalkylene glycol spacer group, and either a reactive site (e.g., a recognition ligand) or a site resistant to non-specific binding (e.g., a methoxy or the like) at the terminus of each modified SAM. The present invention further provides a sensor element, a sensor array and a method of sensing, each employing the composite material. Patterning is also provided together with backfilling to minimize non-specific binding.

摘要翻译： 本发明提供一种复合材料，其包括具有氧化物表面的基材和在氧化物表面上的连续单层，所述单层包含与氧化物表面连接的三官能烷基/烯基/炔基硅烷基团的硅原子，烷基 至少三个碳原子的链烯基/炔基部分，聚亚烷基二醇间隔基，以及反应性位点（例如，识别配体）或对非特异性结合（例如，甲氧基等）具有抗性的位点 每个修饰的SAM的末端。 本发明还提供了各自采用复合材料的传感器元件，传感器阵列和感测方法。 还提供图案化以及回填以最小化非特异性结合。

公开(公告)号：US20100267170A1

公开(公告)日：2010-10-21

申请号：US12777837

申请日：2010-05-11

申请人： Basil I. Swanson ,  Aaron S. Anderson ,  Jurgen G. Schmidt ,  Andrew M. Dattelbaum

发明人： Basil I. Swanson ,  Aaron S. Anderson ,  Jurgen G. Schmidt ,  Andrew M. Dattelbaum

IPC分类号： G01N33/544

CPC分类号： G01N33/54393 ,  G01N33/551 ,  Y10T428/31663

摘要： The present invention provides a composite material including a substrate having an oxide surface, and, a continuous monolayer on the oxide surface, the monolayer including a silicon atom from a trifunctional alkyl/alkenyl/alkynyl silane group that attaches to the oxide surface, an alkyl/alkenyl/alkynyl portion of at least three carbon atoms, a polyalkylene glycol spacer group, and either a reactive site (e.g., a recognition ligand) or a site resistant to non-specific binding (e.g., a methoxy or the like) at the terminus of each modified SAM. The present invention further provides a sensor element, a sensor array and a method of sensing, each employing the composite material. Patterning is also provided together with backfilling to minimize non-specific binding.

摘要翻译： 本发明提供一种复合材料，其包括具有氧化物表面的基材和在氧化物表面上的连续单层，所述单层包含与氧化物表面连接的三官能烷基/烯基/炔基硅烷基团的硅原子，烷基 至少三个碳原子的链烯基/炔基部分，聚亚烷基二醇间隔基，以及反应性位点（例如，识别配体）或对非特异性结合（例如，甲氧基等）具有抗性的位点 每个修饰的SAM的末端。 本发明还提供了各自采用复合材料的传感器元件，传感器阵列和感测方法。 还提供图案化以及回填以最小化非特异性结合。