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21 条记录 (耗时 0.027 秒)

    Robust, self-assembled, biocompatible films
    1.
    发明授权
    Robust, self-assembled, biocompatible films 有权
    坚固的，自组装的生物相容膜

    公开(公告)号：US08759008B2

    公开(公告)日：2014-06-24

    申请号：US12777837

    申请日：2010-05-11

    申请人： Basil I. Swanson ,  Aaron S. Anderson ,  Andrew M. Dattelbaum ,  Jurgen G. Schmidt

    发明人： Basil I. Swanson ,  Aaron S. Anderson ,  Andrew M. Dattelbaum ,  Jurgen G. Schmidt

    IPC分类号： G01N33/53

    CPC分类号： G01N33/54393 ,  G01N33/551 ,  Y10T428/31663

    摘要： The present invention provides a composite material including a substrate having an oxide surface, and, a continuous monolayer on the oxide surface, the monolayer including a silicon atom from a trifunctional alkyl/alkenyl/alkynyl silane group that attaches to the oxide surface, an alkyl/alkenyl/alkynyl portion of at least three carbon atoms, a polyalkylene glycol spacer group, and either a reactive site (e.g., a recognition ligand) or a site resistant to non-specific binding (e.g., a methoxy or the like) at the terminus of each modified SAM. The present invention further provides a sensor element, a sensor array and a method of sensing, each employing the composite material. Patterning is also provided together with backfilling to minimize non-specific binding.

    摘要翻译： 本发明提供一种复合材料，其包括具有氧化物表面的基材和在氧化物表面上的连续单层，所述单层包含与氧化物表面连接的三官能烷基/烯基/炔基硅烷基团的硅原子，烷基 至少三个碳原子的链烯基/炔基部分，聚亚烷基二醇间隔基，以及反应性位点（例如，识别配体）或对非特异性结合（例如，甲氧基等）具有抗性的位点 每个修饰的SAM的末端。 本发明还提供了各自采用复合材料的传感器元件，传感器阵列和感测方法。 还提供图案化以及回填以最小化非特异性结合。

    ROBUST, SELF-ASSEMBLED, BIOCOMPATIBLE FILMS
    2.
    发明申请
    ROBUST, SELF-ASSEMBLED, BIOCOMPATIBLE FILMS 有权
    稳定，自组装，生物易燃膜

    公开(公告)号：US20100267170A1

    公开(公告)日：2010-10-21

    申请号：US12777837

    申请日：2010-05-11

    申请人： Basil I. Swanson ,  Aaron S. Anderson ,  Jurgen G. Schmidt ,  Andrew M. Dattelbaum

    发明人： Basil I. Swanson ,  Aaron S. Anderson ,  Jurgen G. Schmidt ,  Andrew M. Dattelbaum

    IPC分类号： G01N33/544

    CPC分类号： G01N33/54393 ,  G01N33/551 ,  Y10T428/31663

    摘要： The present invention provides a composite material including a substrate having an oxide surface, and, a continuous monolayer on the oxide surface, the monolayer including a silicon atom from a trifunctional alkyl/alkenyl/alkynyl silane group that attaches to the oxide surface, an alkyl/alkenyl/alkynyl portion of at least three carbon atoms, a polyalkylene glycol spacer group, and either a reactive site (e.g., a recognition ligand) or a site resistant to non-specific binding (e.g., a methoxy or the like) at the terminus of each modified SAM. The present invention further provides a sensor element, a sensor array and a method of sensing, each employing the composite material. Patterning is also provided together with backfilling to minimize non-specific binding.

    摘要翻译： 本发明提供一种复合材料，其包括具有氧化物表面的基材和在氧化物表面上的连续单层，所述单层包含与氧化物表面连接的三官能烷基/烯基/炔基硅烷基团的硅原子，烷基 至少三个碳原子的链烯基/炔基部分，聚亚烷基二醇间隔基，以及反应性位点（例如，识别配体）或对非特异性结合（例如，甲氧基等）具有抗性的位点 每个修饰的SAM的末端。 本发明还提供了各自采用复合材料的传感器元件，传感器阵列和感测方法。 还提供图案化以及回填以最小化非特异性结合。

    Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses
    4.
    发明申请
    Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses 审中-公开
    用于流感和相关病毒诊断和抗病毒药物的强大的多齿配体

    公开(公告)号：US20080194801A1

    公开(公告)日：2008-08-14

    申请号：US11728334

    申请日：2007-03-26

    申请人： Basil I. Swanson ,  Jurgen G. Schmidt ,  Suri S. Iyer ,  Ramesh R. Kale

    发明人： Basil I. Swanson ,  Jurgen G. Schmidt ,  Suri S. Iyer ,  Ramesh R. Kale

    IPC分类号： C07H15/00

    CPC分类号： C07H15/00

    摘要： Design and synthesis of a novel library of compounds comprising a spacer with an attachment element on one terminus and a recognition element on the other terminus is presented. The library of compounds can be attached to a solid support and used as an integral component of sensors and biosensors or the library of compounds can be used as antiviral drugs or to isolate pathogens from complex mixtures for further analysis.

    摘要翻译： 提出了一种新型化合物文库的设计和合成，其包括在一个末端具有连接元件的间隔物和另一个末端的识别元件。 化合物库可以连接到固体支持物上，并用作传感器和生物传感器的组成部分，或者化合物文库可以用作抗病毒药物或从复杂混合物中分离病原体进行进一步分析。

    Process for conjugating biomolecules to hydrophobic membrane-incorporated molecules
    6.
    发明申请
    Process for conjugating biomolecules to hydrophobic membrane-incorporated molecules 审中-公开
    将生物分子与疏水性膜结合分子结合的方法

    公开(公告)号：US20110217459A1

    公开(公告)日：2011-09-08

    申请号：US11974970

    申请日：2007-10-16

    申请人： Basil I. Swanson ,  Clifford J. Unkefer ,  Jurgen G. Schmidt ,  Scott M. Reed ,  John E. Shively ,  Lin Li

    发明人： Basil I. Swanson ,  Clifford J. Unkefer ,  Jurgen G. Schmidt ,  Scott M. Reed ,  John E. Shively ,  Lin Li

    IPC分类号： B05D5/06

    CPC分类号： G01N33/5432

    摘要： A process is provided of conjugating a recognition element such as a biomolecule to a hydrophobic multifunctional linker molecule by incorporating a multifunctional linker molecule including one or more anchoring groups, a reporter group and a reactive site thereon into a membrane, and, reacting the membrane including the incorporated multifunctional linker molecule with a pre-selected recognition element to form a covalently bound recognition element-multifunctional linker molecule-membrane assembly. Also, a chemical assembly suitable for subsequent covalent attachment of a recognition element is provided such assembly including a multifunctional linker molecule including one or more anchoring groups, a reporter group, and a hydrophilic spacer terminated by a reactive group capable of subsequent covalent bonding, the one or more anchoring groups incorporated in a membrane.

    摘要翻译： 提供了通过将包括一个或多个锚定基团，报道基团和反应位点的多官能连接分子掺入到膜中，使识别元件例如生物分子与疏水多功能连接分子结合的方法， 所引入的多功能连接分子具有预选的识别元件以形成共价结合的识别元件 - 多功能连接子分子 - 膜组件。 此外，提供适于随后共价连接识别元件的化学组合物，其包括包含一个或多个锚定基团的多官能连接分子，报道基团和由能够随后共价键合的反应性基团封端的亲水性间隔基 一个或多个结合在膜中的锚定基团。

    Solid phase immobilized trifunctional linker
    7.
    发明申请
    Solid phase immobilized trifunctional linker 审中-公开
    固相固定三官能接头

    公开(公告)号：US20100099831A1

    公开(公告)日：2010-04-22

    申请号：US11590109

    申请日：2006-10-30

    申请人： Jurgen G. Schmidt ,  Basil I. Swanson ,  Clifford J. Unkefer

    发明人： Jurgen G. Schmidt ,  Basil I. Swanson ,  Clifford J. Unkefer

    IPC分类号： C08L69/00

    CPC分类号： G01N33/54353 ,  B01J19/0046 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731

    摘要： The present invention is directed to a method of forming an immobilized chemical moiety, such as a trifunctional chemical moiety that includes membrane-anchoring functionalities, on a solid support for use in automated chemical synthesis of a recognition molecule. The invention is further directed to a method of easily and efficiently synthesizing chemical moieties such as those used for biosensor applications. The invention is further directed to a composition, i.e., a solid support having a trifunctional chemical moiety linked thereto, that can be readily and easily used to generate biological molecules for applications, such as biosensor applications.

    摘要翻译： 本发明涉及在用于识别分子的自动化学合成中的固体支持物上形成固定的化学部分例如包括膜锚定功能的三官能化学部分的方法。 本发明进一步涉及容易且有效地合成化学部分的方法，例如用于生物传感器应用的那些。 本发明进一步涉及一种组合物，即具有与其连接的三官能化学部分的固体支持物，其可以容易地和容易地用于产生用于应用的生物分子，例如生物传感器应用。