公开(公告)号：US11098063B2

公开(公告)日：2021-08-24

申请号：US16622233

申请日：2018-06-07

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Martina Delbeck ,  Michael Hahn ,  Thomas Müller ,  Klemens Lustig ,  Karl Collins ,  Niels Lindner ,  Janine Nicolai ,  Moritz Beck-Broichsitter ,  Udo Albus ,  Doris Gehring ,  Björn Rosenstein

IPC分类号： C07D519/00 ,  A61P11/00

摘要： The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

公开(公告)号：US20220259228A1

公开(公告)日：2022-08-18

申请号：US17447795

申请日：2021-09-15

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Martina DELBECK ,  Michael Hahn ,  Thomas Müller ,  Klemens Lustig ,  Johanna Anlahr ,  Udo Albus ,  Doris Gehring ,  Björn Rosenstein ,  Karl Collins ,  Niels Lindner ,  Janine Nicolai ,  Moritz Beck-Broichsitter

IPC分类号： C07D519/00 ,  A61P11/00 ,  G16C20/64 ,  A61K9/00 ,  A61K9/08 ,  A61K31/439 ,  A61K31/444 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/55 ,  A61K45/06

摘要： The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apnoea and central sleep apnoea and snoring. The present application further relates to a method of discovering a compound having TASK-1- and/or TASK-3-blocking properties.

公开(公告)号：US11208422B2

公开(公告)日：2021-12-28

申请号：US16622779

申请日：2018-06-07

申请人： Bayer Pharma Aktiengesellschaft ,  Bayer Aktiengesellschaft

发明人： Martina Delbeck ,  Michael Hahn ,  Thomas Müller ,  Klemens Lustig ,  Johanna Anlahr ,  Karl Collins ,  Janine Nicolai ,  Moritz Beck-Broichsitter ,  Udo Albus ,  Doris Gehring ,  Björn Rosenstein ,  Hongkai Dang ,  Dehe Duan ,  Jianfei Yang ,  Denghui Chen

IPC分类号： C07D519/00 ,  A61P11/00 ,  A61K45/06 ,  A61K31/5513 ,  A61P25/00

摘要： The present application relates to novel imidazopyridinyl- or imidazopyrimidinyl-substituted, bridged 1,4-diazepane derivatives of formula (I), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring. Formula (I) in which the ring Q represents a bridged 1,4-diazepane cycle.