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![Substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-A]pyridine-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-C][1,2,4]triazol-3-ones, and use thereof](/abs-image/US/2020/07/28/US10722501B2/abs.jpg.150x150.jpg)
公开(公告)号：US10722501B2
公开(公告)日：2020-07-28
申请号：US16300480
申请日：2017-05-08
发明人： Nicole Biber , Damian Brockschnieder , Kersten Matthias Gericke , Florian Kölling , Klemens Lustig , Jörg Meding , Heinrich Meier , Thomas Neubauer , Martina Schäfer , Andreas Timmermann , Dmitry Zubov , Carsten Terjung , Niels Lindner , Volker Badock , Dieter Moosmayer , Hideki Miyatake Ondozabal , Stephen Moore , Alexander Schulz
IPC分类号： A61K31/437 , A61K31/506 , C07D471/04 , A61K31/4375 , A61K31/4709 , A61K31/497 , C07D519/00 , A61K45/06 , A61K31/444 , A61P11/00 , A61P29/00
摘要： The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones of formula (I), to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.
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公开(公告)号：US11208400B2
公开(公告)日：2021-12-28
申请号：US16341410
申请日：2017-10-09
发明人： Anja Giese , Jürgen Klar , Alexander Helmut Michael Ehrmann , Jens Willwacher , David Engel , Andre Philippe Dieskau , Antje Kahnert , Alexey Gromov , Carsten Schmeck , Niels Lindner , Thomas Müller , Anna Lena Andreevski , Jan Dreher , Karl Collins
IPC分类号： C07D403/14 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.
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3.发明授权公开(公告)号：US11098063B2
公开(公告)日：2021-08-24
申请号：US16622233
申请日：2018-06-07
发明人： Martina Delbeck , Michael Hahn , Thomas Müller , Klemens Lustig , Karl Collins , Niels Lindner , Janine Nicolai , Moritz Beck-Broichsitter , Udo Albus , Doris Gehring , Björn Rosenstein
IPC分类号： C07D519/00 , A61P11/00
摘要： The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.
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公开(公告)号：US20220259228A1
公开(公告)日：2022-08-18
申请号：US17447795
申请日：2021-09-15
发明人： Martina DELBECK , Michael Hahn , Thomas Müller , Klemens Lustig , Johanna Anlahr , Udo Albus , Doris Gehring , Björn Rosenstein , Karl Collins , Niels Lindner , Janine Nicolai , Moritz Beck-Broichsitter
IPC分类号： C07D519/00 , A61P11/00 , G16C20/64 , A61K9/00 , A61K9/08 , A61K31/439 , A61K31/444 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K45/06
摘要： The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apnoea and central sleep apnoea and snoring. The present application further relates to a method of discovering a compound having TASK-1- and/or TASK-3-blocking properties.
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公开(公告)号：US11173151B2
公开(公告)日：2021-11-16
申请号：US16756623
申请日：2018-10-17
发明人： Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Hanna Tinel , Niels Lindner , Heiko Schirmer
IPC分类号： A61K31/4439 , A61K31/4188 , A61K31/4196 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/10
摘要： The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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![Amino-substituted imidazo[1,2-A] pyridinecarboxamides and their use](/abs-image/US/2020/05/26/US10662185B2/abs.jpg.150x150.jpg)
公开(公告)号：US10662185B2
公开(公告)日：2020-05-26
申请号：US16025087
申请日：2018-07-02
发明人： Alexandros Vakalopoulos , Markus Follman , Ingo Hartung , Philipp Buchgraber , Rolf Jautelat , Jorma Haßfeld , Niels Lindner , Alexey Gromov , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Andreas Knorr
IPC分类号： C07D471/04 , A61K31/437 , A61K31/439 , A61K31/4985 , A61K45/06 , C07D471/08 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D519/00 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/55 , A61K31/4375 , A61K31/4725
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides of the general formula (I) to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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![AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE](/abs-image/US/2015/10/01/US20150274719A1/abs.jpg.150x150.jpg)
7.发明申请公开(公告)号：US20150274719A1
公开(公告)日：2015-10-01
申请号：US14440509
申请日：2013-11-04
发明人： Alexandros Vakalopoulos , Markus Follmann , Ingo Hartung , Philipp Buchgraber , Rolf Jautelat , Jorma Hassfeld , Niels Lindner , Alexey Gromov , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Andreas Knorr
IPC分类号： C07D471/04 , A61K31/437 , A61K45/06 , A61K31/496 , A61K31/541 , A61K31/4985 , C07D519/00 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/08 , C07D519/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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![Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2018/08/21/US10052312B2/abs.jpg.150x150.jpg)
公开(公告)号：US10052312B2
公开(公告)日：2018-08-21
申请号：US15447205
申请日：2017-03-02
发明人： Alexandros Vakalopoulos , Markus Follmann , Ingo Hartung , Philipp Buchgraber , Rolf Jautelat , Jorma Haβfeld , Niels Lindner , Alexey Gromov , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Andreas Knorr
IPC分类号： A61K31/437 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4985 , A61K31/439 , A61K31/4709 , A61K31/4545 , A61K31/444 , A61K31/55
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/08 , C07D519/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US09598416B2
公开(公告)日：2017-03-21
申请号：US14365024
申请日：2012-12-11
发明人： Marie-Pierre Collin , Dirk Brohm , Mélanie Héroult , Mario Lobell , Walter Hübsch , Klemens Lustig , Sylvia Grünewald , Ulf Bömer , Verena Vöhringer , Niels Lindner
IPC分类号： C07D487/04 , C07D409/04 , C07D409/14 , A61K31/53 , A61K31/382 , A61P35/00 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/553
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/553 , C07D409/04 , C07D409/14
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-fJ[1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
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10.发明申请SUBSTITUTED AMINOINDANE- AND AMINOTETRALINECARBOXYLIC ACIDS AND THE USE THEREOF 有权取代的氨基氨基和氨基甲酰氧基酸及其用途公开(公告)号：US20150174113A1
公开(公告)日：2015-06-25
申请号：US14414297
申请日：2013-07-16
发明人： Walter Hübsch , Michael Hahn , Alexandros Vakalopoulos , Volkhart Min-Jian Li , Frank Wunder , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Friederike Stoll , Niels Lindner , Eva Maria Becker-Pelster
IPC分类号： A61K31/45 , C07C227/18 , A61K31/197 , A61K45/06 , C07D211/76 , A61K31/4015 , C07D263/22 , A61K31/421 , C07D231/12 , A61K31/415 , C07C229/50 , C07D207/27
CPC分类号： A61K31/45 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/2059 , A61K31/197 , A61K31/24 , A61K31/277 , A61K31/4015 , A61K31/415 , A61K31/421 , A61K45/06 , C07C227/18 , C07C229/50 , C07C255/54 , C07C2602/08 , C07C2602/10 , C07D207/27 , C07D211/76 , C07D231/12 , C07D263/22 , A61K2300/00
摘要： The present application relates to novel substituted aminoindane- and aminotetralinecarboxylic acids, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular and cardiopulmonary diseases.
摘要翻译： 本申请涉及新型取代氨基茚满和氨基四氢萘羧酸，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途， 特别是用于治疗和/或预防心血管和心肺疾病。
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