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公开(公告)号：US11286263B2
公开(公告)日：2022-03-29
申请号：US16764563
申请日：2018-11-15
发明人： Steven James Ferrara , Michael H. Serrano-Wu , Chris Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Laura Furst , Guo Wei , Patrick Ryan McCarren , Kai Thede , Anne Mengel , Clara Christ , Joachim Kuhnke , Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Ulrike Sack , Stefan Kaulfuss , Amaury Ernesto Fernandez-Montalvan , Nicolas Werbeck , Ursula Mönning
IPC分类号： C07D487/14 , C07D403/14 , C07D498/14 , A61K31/4162 , A61P35/00
摘要： The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20210292341A1
公开(公告)日：2021-09-23
申请号：US16764672
申请日：2018-11-15
发明人： Laura Furst , Michael H. Serrano-Wu , Christopher Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Steven James Ferrara , Guo Wei , Patrick Ryan McCarren , Kai Thede , Anne Mengel , Clara Christ , Joachim Kuhnke , Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Ulrike Sack , Stefan Kaulfuss , Amaury Ernesto Fernandez-Montalvan , Nicolas Werbeck , Ursula Mönning , Katrin Nowak-Reppel
IPC分类号： C07D513/14 , A61K31/5377 , A61K31/4162 , A61K31/454 , A61K45/06 , A61P35/02 , A61P35/00
摘要： The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20210269456A1
公开(公告)日：2021-09-02
申请号：US16764668
申请日：2018-11-15
发明人： Kai Thede , Anne Mengel , Clara Christ , Joachim Kuhnke , Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Ulrike Sack , Stefan Kaulfuss , Amaury Ernesto Fernandez-Montalvan , Nicolas Werbeck , Ursula Mönning , Katrin Nowak-Reppel , Sven Wittrock , David McKinney , Michael H. Serrano-Wu , Christopher Lemke , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Steven James Ferrara , Laura Furst , Guo Wei , Patrick Ryan McCarren , Rebecca Ann Harvey
IPC分类号： C07D498/14 , A61K31/4162 , A61K31/5377 , C07D498/22 , C07D487/14 , C07D471/22 , C07D487/22 , A61P35/00 , A61P35/02 , A61K45/06 , A61K31/496 , A61K31/437
摘要： The present invention relates to substituted macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11492358B1
公开(公告)日：2022-11-08
申请号：US17186820
申请日：2021-02-26
发明人： Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Clara Christ , Kai Thede , Joachim Kuhnke , Manfred Moewes , Knut Eis , Amaury Ernesto Fernandez-Montalvan , Nicolas Werbeck , Ursula Mönning , Philip Lienau , Ulrike Sack , Arne Scholz , Michael H. Serrano-Wu , Christopher Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Steven James Ferrara , Laura Furst , Guo Wei , Patrick Ryan McCarren
IPC分类号： C07D498/16 , C07D498/06 , C07D498/22 , C07D487/16
摘要： The present invention relates to macrocyclic indole derivatives of general formula (I) in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20210277022A1
公开(公告)日：2021-09-09
申请号：US16764675
申请日：2018-11-15
发明人： Kai Thede , Anne Mengel , Clara Christ , Joachim Kuhnke , Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Ulrike Sack , Stefan Kaulfuss , Amaury Ernesto Fernandez-Montalvan , Nicolas Werbeck , Ursula Mönning , Katrin Nowak-Reppel , Jeremie Xavier Mortier , Patrick Ryan McCarren , Michael H. Serrano-Wu , Christopher Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Steven James Ferrara , Laura Furst , Guo Wei , Rebecca Ann Flarvey , Daniel Payne , Thomas Pesnot , Craig Wilson
IPC分类号： C07D498/14 , C07D487/14 , A61K45/06
摘要： The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20210253598A1
公开(公告)日：2021-08-19
申请号：US16764560
申请日：2018-11-15
发明人： Kai Thede , Anne Mengel , Clara Christ , Joachim Kuhnke , Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Ulrike Sack , Stefan Kaulfuss , Amaury Ernesto Fernandez-Montalvan , Nicolas Werbeck , Ursula Mönning , Steven James Ferrara , Michael H. Serrano-Wu , Christopher Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Laura Furst , Guo Wei , Patrick Ryan MacCarren , Rebecca Ann Harvey , Craig Wilson
IPC分类号： C07D498/14 , A61K45/06 , C07D498/22 , A61K31/437 , A61K31/4162 , A61K31/4985 , C07D487/14 , A61K31/424 , A61P35/00 , A61P35/02
摘要： The present invention relates to aryl annulated macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US10981932B2
公开(公告)日：2021-04-20
申请号：US16301871
申请日：2017-05-17
发明人： Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Clara Christ , Kai Thede , Joachim Kuhnke , Manfred Moewes , Knut Eis , Amaury Fernandez-Montalvan , Nicolas Werbeck , Ursula Moenning , Philip Lienau , Ulrike Sack , Arne Scholz , Michael H. Serrano-Wu , Chris Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Steven James Ferrara , Laura Furst , Guo Wei , Patrick R. McCarren
IPC分类号： C07D498/16 , C07D498/06 , C07D498/22 , C07D487/16
摘要： The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical 2019 compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11691986B2
公开(公告)日：2023-07-04
申请号：US17558390
申请日：2021-12-21
发明人： Ulrich Lücking , Daniel Hog , Clara Christ , Ulrike Sack , Franziska Siegel , Philip Lienau , Nicolas Werbeck
IPC分类号： C07D213/61 , C07D498/18 , C07D239/30 , C07D498/08
CPC分类号： C07D498/18 , C07D213/61 , C07D239/30 , C07D498/08
摘要： The present invention relates to novel modified macrocyclic compounds with improved tolerability of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
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公开(公告)号：US20200087322A1
公开(公告)日：2020-03-19
申请号：US16301871
申请日：2017-05-17
发明人： Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Clara Christ , Kai Thede , Joachim Kuhnke , Manfred Moewes , Knut Eis , Amaury Fernandez-Montalvan , Nicolas Werbeck , Ursula Moenning , Philip Lienau , Ulrike Sack , Arne Scholz , Michael H. Serrano-Wu , Chris Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Steven James Ferrara , Laura Furst , Guo Wei , Patrick R. McCarren
IPC分类号： C07D498/16 , C07D487/16 , C07D498/22 , C07D498/06
摘要： The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11254690B2
公开(公告)日：2022-02-22
申请号：US16498662
申请日：2018-03-22
发明人： Ulrich Lücking , Daniel Hog , Clara Christ , Ulrike Sack , Franziska Siegel , Philip Lienau , Nicolas Werbeck
IPC分类号： C07D498/18 , A61P35/00 , C07D498/08
摘要： The present invention relates to novel modified macrocyclic compounds with improved tolerability of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
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