公开(公告)号：US11998539B2

公开(公告)日：2024-06-04

申请号：US18072490

申请日：2022-11-30

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft ,  Deutsches Krebsforschungszentrum

发明人： Norbert Schmees ,  Lars Wortmann ,  Dennis Kirchhoff ,  Thi Thanh Uyen Nguyen ,  Nicolas Werbeck ,  Ulf Bömer ,  Kirstin Petersen ,  Christina Kober ,  Christian Lechner ,  Dirk Kosemund ,  Rienk Offringa ,  Mareike Grees ,  Benjamin Bader

IPC分类号： A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/498 ,  A61K31/55 ,  A61K45/06 ,  A61P35/00 ,  A61P37/04 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

CPC分类号： A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/498 ,  A61K31/55 ,  A61K45/06 ,  A61P35/00 ,  A61P37/04 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.

公开(公告)号：US20230391769A1

公开(公告)日：2023-12-07

申请号：US18018216

申请日：2021-07-27

申请人： Bayer Aktiengesellschaft ,  The Broad Institute, Inc. ,  Dana-Farber Cancer Institute, Inc.

发明人： Volker Schulze ,  Anne Mengel ,  Adelaide Clara Faria Alvares De Lemos ,  Sven Christian ,  Ulf Bömer ,  Roman Hillig ,  Christian Lechner ,  Jérémie Xavier Mortier ,  Stefan Kaulfuss ,  Steven Corsello ,  Katarzyna Handing ,  Amael Madec ,  Laura Furst ,  Mrinal Shekhar ,  Markus Berger ,  Rajesha Rupaimoole ,  Philip Lienau ,  Douglas Orsi ,  David McKinney ,  Krzysztof Brezezinka

IPC分类号： C07D471/04 ,  C07D401/06 ,  C07F7/08 ,  C07D401/14 ,  C07D405/14 ,  C07D487/04 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D401/06 ,  C07F7/0812 ,  C07D401/14 ,  C07D405/14 ,  C07D487/04 ,  A61P35/00

摘要： Compounds of formula (I), process for their production and their use as pharmaceuticals.

公开(公告)号：US20230365554A1

公开(公告)日：2023-11-16

申请号：US18018148

申请日：2021-07-27

申请人： The Broad Institute, Inc. ,  Bayer Aktiengesellschaft ,  Dana-Farber Cancer Institute, Inc.

发明人： Volker Schulze ,  Anne Mengel ,  Adelaide Clara Faria Alvares De Lemos ,  Ulrike Rauh ,  Ulf Bömer ,  Roman Hillig ,  Christian Lechner ,  Jeremie Xavier G. Mortier ,  Detlev Sülzle ,  Stefan Kaulfuss ,  Steven Corsello ,  Katarzyna Handing ,  Alisha Caliman ,  Amael Madec

IPC分类号： C07D471/04 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61P35/00

摘要： Compounds of formula (I), process for their production and their use as pharmaceuticals.

公开(公告)号：US20230322767A1

公开(公告)日：2023-10-12

申请号：US18018207

申请日：2021-07-27

申请人： Bayer Aktiengesellschaft ,  The Broad Institute, Inc. ,  Dana-Farber Cancer Institute, Inc.

发明人： Volker Schulze ,  Anne Mengel ,  Adelaide Clara Faria Alvares De Lemos ,  Ulrike Rauh ,  Ulf Bömer ,  Roman Hillig ,  Christian Lechner ,  Jérémie Xavier Mortier ,  Stefan Kaulfuss ,  Steven Corsello ,  Katarzyna Handing ,  Amael Madec ,  Laura Furst ,  Mrinal Shekhar ,  David McKinney

IPC分类号： C07D471/04 ,  A61K45/06

CPC分类号： C07D471/04 ,  A61K45/06

摘要： Compounds of formula (I), process for their production and their use as pharmaceuticals.

公开(公告)号：US20230339939A1

公开(公告)日：2023-10-26

申请号：US18018221

申请日：2021-07-27

申请人： Bayer Aktiengesellschaft ,  The Broad Institute, Inc. ,  Dana-Farber Cancer Institute, Inc.

发明人： Volker Schulze ,  Anne Mengel ,  Adelaide Clara Faria Alvares De Lemos ,  Sven Christian ,  Ulf Bömer ,  v Hillig ,  Christian Lechner ,  Jérémie Xavier Mortier ,  Stefan Kaulfuss ,  Steven Corsello ,  Katarzyna Handing ,  Amael Madec ,  Laura Furst ,  Mrinal Shekhar ,  Markus Berger ,  Rajesha Rupaimoole ,  Philip Lienau ,  Douglas Orsi ,  David McKinney ,  Krzysztof Brezezinka

IPC分类号： C07D471/04 ,  C07D487/04

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Compounds of formula (I), process for their production and their use as pharmaceuticals.

公开(公告)号：US20230046077A1

公开(公告)日：2023-02-16

申请号：US17428730

申请日：2020-02-06

申请人： Bayer Aktiengesellschaft ,  Dana-Farber Cancer Institute, Inc. ,  The Broad Institute, Inc.

发明人： Volker Schulze ,  Anne Mengel ,  Jens Schroeder ,  Adelaide Clara Faria Alvares De Lemos ,  Wilhelm Bone ,  Ulf Bomer ,  Detlev Sulzle ,  Clara Christ ,  Roman Hillig ,  Christian Lechner ,  Steven Corsello ,  Kasia Handing ,  Alisha Caliman ,  Ulrike Rauh ,  Stefan Kaulfuss ,  Jérémie Mortier

IPC分类号： C07D471/04 ,  A61P35/00

摘要： The present invention relates to compounds of formula (I) processes for their production and their use as pharmaceuticals. The compounds are inhibitors of Casein kinase 1 alpha and/or delta (CSNK1α and/or β) useful for the treatment of proliferative disorders.