公开(公告)号：US20230148194A1

公开(公告)日：2023-05-11

申请号：US17780890

申请日：2020-11-24

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft ,  Deutsches Krebsforschungszentrum

发明人： Norbert SCHMEES ,  Lars WORTMANN ,  DENNIS KIRCHHOFF ,  Thi Thanh Uyen NGUYEN ,  Nicolas WERBECK ,  Ulf BÖMER ,  Kirstin PETERSEN ,  Christina KOBER ,  Detlef STÖCKIGT ,  Christian LECHNER ,  Robin Michael MEIER ,  Simon Anthony HERBERT ,  Isabel Patrizia KERSCHGENS ,  DIRK KOSEMUND ,  Rienk OFFRINGA ,  Mareike GREES

IPC分类号： A61K31/4545 ,  C07D413/14 ,  C07D401/14 ,  C07D401/04 ,  C07D417/14 ,  C07D405/14 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/55 ,  A61K45/06 ,  A61P35/00 ,  A61P37/04

CPC分类号： A61K31/4545 ,  C07D413/14 ,  C07D401/14 ,  C07D401/04 ,  C07D417/14 ,  C07D405/14 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4725 ,  A61K31/498 ,  A61K31/55 ,  A61K45/06 ,  A61P35/00 ,  A61P37/04

摘要： The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.