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公开(公告)号：US20230201186A1
公开(公告)日：2023-06-29
申请号：US18072490
申请日：2022-11-30
发明人： Norbert SCHMEES , Lars WORTMANN , Dennis KIRCHOFF , Thi Thanh Uyen NGUYEN , Nicolas WERBECK , Ulf BÖMER , Kirstin PETERSEN , Christina KOBER , Detlef STÖCKIGT , Christian LECHNER , Robin Michael MEIER , Simon Anthony HERBERT , Isabel Patrizia KERSCHGENS , Dirk KOSEMUND , Rienk OFFRINGA , Mareike GREES
IPC分类号： A61K31/4545 , C07D401/14 , A61K31/498 , C07D413/14 , A61P37/04 , A61K31/55 , C07D401/04 , C07D405/14 , C07D417/14 , A61K31/496 , A61K31/4725 , A61P35/00 , A61K31/4709 , A61K45/06
CPC分类号： A61K31/4545 , C07D401/14 , A61K31/498 , C07D413/14 , A61P37/04 , A61K31/55 , C07D401/04 , C07D405/14 , C07D417/14 , A61K31/496 , A61K31/4725 , A61P35/00 , A61K31/4709 , A61K45/06
摘要： The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230064809A1
公开(公告)日：2023-03-02
申请号：US17780814
申请日：2020-11-24
发明人： Norbert SCHMEES , Lars WORTMANN , Dennis KIRCHHOFF , Thi Thanh Uyen NGUYEN , Nicolas WERBECK , Ulf BÖMER , Kirstin PETERSEN , Christina KOBER , Detlef STÖCKIGT , Christian LECHNER , Rienk OFFRINGA
IPC分类号： A61K31/4709 , C07D471/10 , C07D487/10 , A61K31/5377 , A61K31/496 , A61P37/04 , A61P35/00 , A61K45/06
摘要： The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, m, n, o and p are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230148194A1
公开(公告)日：2023-05-11
申请号：US17780890
申请日：2020-11-24
发明人： Norbert SCHMEES , Lars WORTMANN , DENNIS KIRCHHOFF , Thi Thanh Uyen NGUYEN , Nicolas WERBECK , Ulf BÖMER , Kirstin PETERSEN , Christina KOBER , Detlef STÖCKIGT , Christian LECHNER , Robin Michael MEIER , Simon Anthony HERBERT , Isabel Patrizia KERSCHGENS , DIRK KOSEMUND , Rienk OFFRINGA , Mareike GREES
IPC分类号： A61K31/4545 , C07D413/14 , C07D401/14 , C07D401/04 , C07D417/14 , C07D405/14 , A61K31/4709 , A61K31/496 , A61K31/4725 , A61K31/498 , A61K31/55 , A61K45/06 , A61P35/00 , A61P37/04
CPC分类号： A61K31/4545 , C07D413/14 , C07D401/14 , C07D401/04 , C07D417/14 , C07D405/14 , A61K31/4709 , A61K31/496 , A61K31/4725 , A61K31/498 , A61K31/55 , A61K45/06 , A61P35/00 , A61P37/04
摘要： The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230062100A1
公开(公告)日：2023-03-02
申请号：US17780903
申请日：2020-11-24
发明人： Norbert SCHMEES , Lars WORTMANN , DENNIS KIRCHOFF , Thi Thanh Uyen NGUYEN , Nicolas WERBECK , Ulf BÖMER , Kirstin PETERSEN , Christina KOBER , Detlef STÖCKIGT , Christian LECHNER , Robin Michael MEIER , Simon Anthony HERBERT , Isabel Patrizia KERSCHGENS , DIRK KOSEMUND , Julien LEFRANC , Rienk OFFRINGA
IPC分类号： A61K31/4709 , C07D401/04 , C07D401/14 , C07D413/14 , C07D405/14 , C07F9/6558 , C07D417/14 , A61K31/513 , A61K31/496 , A61K31/506 , A61K31/675 , A61K31/55 , A61P37/04 , A61P35/00 , A61K45/06
摘要： The present invention covers aminoquinolone compounds of general formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8, X and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230167103A1
公开(公告)日：2023-06-01
申请号：US17921043
申请日：2021-04-20
发明人： Norbert SCHMEES , Ulrike ROEHN , Dennis KIRCHHOFF , Kirstin PETERSEN , Thi Thanh Uyen NGUYEN , Mareike GREES , Nicolas WERBECK , Ulf BOEMER , Benjamin BADER , Detlef STOECKIGT , Rienk OFFRINGA , Corinna LINK , Giambattista TESTOLIN , Katrin NOWAK-REPPEL
IPC分类号： C07D417/06 , C07D417/14 , C07K16/28 , A61P35/00
CPC分类号： C07D417/06 , C07D417/14 , C07K16/2818 , C07K16/2827 , A61P35/00
摘要： The present invention covers aminothiazole compounds of general formula (I): in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase zeta (DGKζ) regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230167078A1
公开(公告)日：2023-06-01
申请号：US17920679
申请日：2021-04-20
发明人： Norbert SCHMEES , Ulrike ROEHN , Dennis KIRCHHOFF , Kirstin PETERSEN , Thi Thanh Uyen NGUYEN , Mareike GREES , Nicolas WERBECK , Ulf BOEMER , Benjamin BADER , Detlef STOECKIGT , Dirk KOSEMUND , Rienk OFFRINGA , Corinna LINK , Katrin NOWAK-REPPEL
IPC分类号： C07D277/46 , C07D417/06 , C07D417/12 , C07D487/04 , C07D417/14 , C07K16/28 , C07D417/10 , C07D471/08 , A61P35/00
CPC分类号： C07D277/46 , C07D417/06 , C07D417/12 , C07D487/04 , C07D417/14 , C07K16/2818 , C07K16/2827 , C07D417/10 , C07D471/08 , A61P35/00 , C07B2200/07
摘要： The present invention covers aminothiazole compounds of general formula (I), in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase zeta (DGKζ) regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230139936A1
公开(公告)日：2023-05-04
申请号：US17944922
申请日：2022-09-14
发明人： Norbert SCHMEES , Ulrike ROEHN , Dennis KIRCHHOFF , Kirstin PETERSEN , Mareike GREES , Nicolas WERBECK , Benjamin BADER , Rienk OFFRINGA , Corinna LINK
IPC分类号： C07D277/42 , A61P35/00
摘要： The present invention covers aminothiazole compounds of general formula (I), in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase zeta (DGKζ) regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20150376189A1
公开(公告)日：2015-12-31
申请号：US14764843
申请日：2014-01-28
发明人： Ludwig ZORN , Knut EIS , Volker SCHULZE , Detlev SÜLZLE , Florian PUEHLER , Philip LIENAU , Ulf BÖMER , Kirstin PETERSEN , Andrea HÄGEBARTH
IPC分类号： C07D487/04 , C07D491/048 , A61K31/513 , A61K45/06 , A61K31/5025
CPC分类号： C07D487/04 , A61K31/5025 , A61K31/513 , A61K45/06 , C07D491/04 , C07D491/048
摘要： The present invention relates to amido-substituted imidazopyridazine compounds of general formula (I): in which A, R1, R2, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的酰氨基取代的咪唑并哒嗪化合物：其中A，R1，R2，R3，R4和n如权利要求中所定义，涉及制备所述化合物的方法，可用于制备 所述化合物，包含所述化合物的药物组合物和组合以及用于制备用于治疗或预防疾病，特别是高增殖性和/或血管生成障碍的药物组合物的所述化合物用作单一药剂或 与其他活性成分组合。
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公开(公告)号：US20220235013A1
公开(公告)日：2022-07-28
申请号：US16496825
申请日：2018-03-19
发明人： Lars WORTMANN , Brice SAUTIER , Knut EIS , Hans BRIEM , Niels BOHNKE , Franz VON NUSSBAUM , Roman HILLIG , Benjamin BADER , Jens SCHRODER , Kirstin PETERSEN , Philip LIENAU , Antje Margret WENGNER , Dieter MOOSMAYER , Qiuwen WANG , Hans SCHICK
IPC分类号： C07D239/94 , C07D409/12 , C07D405/12 , C07D403/12 , C07D417/12 , C07D471/04 , C07D413/12 , C07D401/12 , C07D409/14 , C07D413/14
摘要： The present invention describes 2-methyl-quinazoline compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions.
The 2-methyl substituted quinazoline compounds of general formula (I) effectively and selectively inhibit the Ras-Sos interaction without significantly targeting the EGFR receptor. They are therefore useful for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, such as cancer as a sole agent or in combination with other active ingredients.-
公开(公告)号：US20170197979A1
公开(公告)日：2017-07-13
申请号：US15312838
申请日：2015-05-26
发明人： Anja GIESE , Ulrich KLAR , Georg KETTSCHAU , Detlev SÜLZLE , Philip LIENAU , Kirstin PETERSEN
IPC分类号： C07D495/04 , A61K31/541 , A61K31/5377 , C07D519/00 , A61K31/519 , A61K45/06
CPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D519/00
摘要： The present invention relates to substituted benzothiadiazolamine compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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