专利检索 ap:("Bayer Aktiengesellschaft" OR "Bayer Pharma Aktiengesellschaft" OR "The Broad Institute, Inc." OR "Dana-Farber Cancer Institute, Inc.") AND inv:"Bethany KAPLAN" 第 1 页

1.

发明公开
N-[2-({4-[3-(ANILINO)-4-OXO-4,5,6,7-TETRAHYDRO-1H-PYRROLO[3,2-C]PYRIDIN-2-YL]PYRIDIN-3-YL)OXY)ETHYL]PROP-2-ENAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开

公开(公告)号：US20230416249A1

公开(公告)日：2023-12-28

申请号：US18315472

申请日：2023-05-10

申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.

发明人： Stephan SIEGEL , Franziska SIEGEL , Volker SCHULZE , Markus BERGER , Keith GRAHAM , Ulrich KLAR , Jeremie Xavier G. MORTIER , Detlev SÜLZLE , Ulf BÖMER , Daniel KORR , Jens SCHRÖDER , Matthew MEYERSON , Heidi GREULICH , Bethany KAPLAN

IPC分类号： C07D471/04 , A61P35/00 , G01N33/574

CPC分类号： C07D471/04 , A61P35/00 , G01N33/57492 , G01N2333/71

摘要： Compounds of formula (I)

processes for their production and their use as pharmaceuticals.

2.

发明申请
3-(ANILINO)-2-[3-(3-ALKOXY-PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER 有权

公开(公告)号：US20230064983A1

公开(公告)日：2023-03-02

申请号：US17934553

申请日：2022-09-22

申请人： Bayer Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.

发明人： Stephan SIEGEL , Franziska SIEGEL , Volker SCHULZE , Markus BERGER , Jeremie Xavier G. MORTIER , Detlev SÜLZLE , Ulf BÖMER , Daniel KORR , Jens SCHRÖDER , Ursula MÖNNING , Michael NIEHUES , Matthew MEYERSON , Heidi GREULICH , Bethany KAPLAN

IPC分类号： A61K31/444 , C07D471/04 , A61K31/5377 , A61K31/4545 , A61K45/06

摘要： Compounds of formula (I) processes for their production and their use as pharmaceuticals.

3.

发明公开
4H-PYRROLO[3,2-c]PYRIDIN-4-ONE COMPOUNDS 审中-公开

公开(公告)号：US20240307362A1

公开(公告)日：2024-09-19

申请号：US17605956

申请日：2020-04-22

申请人： Bayer Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.

发明人： Stephan SIEGEL , Franziska SIEGEL , Volker SCHULZE , Markus BERGER , Keith GRAHAM , Stefan Nikolaus GRADL , Detlev SÜLZLE , Ulf BÖMER , Daniel KORR , Jens SCHRÖDER , Ursula MÖNNING , Michael NIEHUES , Matthew MEYERSON , Heidi GREULICH , Bethany KAPLAN , Hassan Youssef HARB , Phi Manh DINH

IPC分类号： A61K31/444 , A61K45/06 , A61P35/00 , C07D471/04 , C12Q1/6886 , G01N33/574

CPC分类号： A61K31/444 , A61K45/06 , A61P35/00 , C07D471/04 , C12Q1/6886 , G01N33/57484 , C12Q2600/106 , C12Q2600/156 , G01N2333/71

摘要： Compounds of formula (I), processes for their production and their use as pharmaceuticals are described herein.

4.

发明申请
4H-PYRROLO[3,2-C]PYRIDIN-4-ONE DERIVATIVES 有权

公开(公告)号：US20220378762A1

公开(公告)日：2022-12-01

申请号：US17605990

申请日：2020-04-22

申请人： Bayer Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.

发明人： Franziska SIEGEL , Daniel KORR , Jens SCHRÖDER , Stephan SIEGEL , Heidi GREULICH , Bethany KAPLAN , Matthew MEYERSON

IPC分类号： A61K31/444 , A61K38/17 , A61K45/06 , A61P35/00 , C07D471/04 , A61K31/5377 , A61K31/4545

摘要： Compounds of formula (I) for use in the treatment or prophylaxis of a disease, which is a hyperproliferative disease and/or a disorder responsive to induction of cell death, selected from a haematological tumour, a solid tumour and/or metastases thereof, said tumour harbouring a mutant EGFR with exon 19 or 21 mutations, and their use as pharmaceuticals.

5.

发明申请
4H-PYRROLO[3,2-C]PYRIDIN-4-ONE COMPOUNDS 有权

公开(公告)号：US20220298157A1

公开(公告)日：2022-09-22

申请号：US17605975

申请日：2020-04-22

申请人： Bayer Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.

发明人： Stephan SIEGEL , Franziska SIEGEL , Volker SCHULZE , Markus BERGER , Keith GRAHAM , Detlev SÜLZLE , Ulf BÖMER , Daniel KORR , Jens SCHRÖDER , Ursula MÖNNING , Michael NIEHUES , Matthew MEYERSON , Heidi GREULICH , Bethany KAPLAN

IPC分类号： C07D471/04 , A61K31/437 , A61K45/06 , A61K31/5377 , A61P35/00

摘要： Compounds of formula (I), formula (I), processes for their production and their R use as pharmaceuticals.